論文
(8) シグナル伝達・代謝関連　(signaling・metabolism)

Oxygen-Glucose Deprived Peripheral Blood Mononuclear Cells Protect Against Ischemic Stroke.
Otsu Y, Hatakeyama M, Kanayama T, Akiyama N, Ninomiya I, Omae K, Kato T, Onodera O, Fukushima M, Shimohata T, Kanazawa M.
Neurotherapeutics. 2023 Jun 19.
https://pubmed.ncbi.nlm.nih.gov/37335500/

Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells.
Murano T, Okamoto R, Ito G, Nakata T, Hibiya S, Shimizu H, Fujii S, Kano Y, Mizutani T, Yui S, Akiyama-Morio J, Nemoto Y, Tsuchiya K, Nakamura T, Watanabe M.
Biochem Biophys Res Commun. 2014 Jan 17;443(3):840-6. doi: 10.1016/j.bbrc.2013.12.061. Epub 2013 Dec 14.
https://pubmed.ncbi.nlm.nih.gov/24342613/

A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease.
Fujiwara T, Ikeda T, Nagasaka Y, Okitsu Y, Katsuoka Y, Fukuhara N, Onishi Y, Ishizawa K, Ichinohasama R, Tomosugi N, Harigae H.
PLoS One. 2013 Sep 27;8(9):e75568. doi: 10.1371/journal.pone.0075568. eCollection 2013.
https://pubmed.ncbi.nlm.nih.gov/24086573/

YAP is essential for tissue tension to ensure vertebrate 3D body shape.
Porazinski S, Wang H, Asaoka Y, Behrndt M, Miyamoto T, Morita H, Hata S, Sasaki T, Krens SFG, Osada Y, Asaka S, Momoi A, Linton S, Miesfeld JB, Link BA, Senga T, Shimizu N, Nagase H, Matsuura S, Bagby S, Kondoh H, Nishina H, Heisenberg CP, Furutani-Seiki M.
Nature. 2015 May 14;521(7551):217-221. doi: 10.1038/nature14215. Epub 2015 Mar 16.
https://pubmed.ncbi.nlm.nih.gov/25778702/

Normalization of Overexpressed α-Synuclein Causing Parkinson's Disease By a Moderate Gene Silencing With RNA Interference.
Takahashi M, Suzuki M, Fukuoka M, Fujikake N, Watanabe S, Murata M, Wada K, Nagai Y, Hohjoh H.
Mol Ther Nucleic Acids. 2015 May 12;4:e241. doi: 10.1038/mtna.2015.14.
https://pubmed.ncbi.nlm.nih.gov/25965551/

Direct observation of DNA alterations induced by a DNA disruptor.
Ohshiro T, Asai A, Konno M, Ohkawa M, Komoto Y, Ofusa K, Ishii H, Taniguchi M.
Sci Rep. 2022 Apr 28;12(1):6945. doi: 10.1038/s41598-022-10725-8.
https://pubmed.ncbi.nlm.nih.gov/35484163/

Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells.
Kamei S, Fujikawa H, Nohara H, Ueno-Shuto K, Maruta K, Nakashima R, Kawakami T, Matsumoto C, Sakaguchi Y, Ono T, Suico MA, Boucher RC, Gruenert DC, Takeo T, Nakagata N, Li JD, Kai H, Shuto T.
EBioMedicine. 2018 Jan;27:304-316. doi: 10.1016/j.ebiom.2017.12.025. Epub 2017 Dec 20.
https://pubmed.ncbi.nlm.nih.gov/29289532/

Ubiquitin D is Upregulated by Synergy of Notch Signalling and TNF-α in the Inflamed Intestinal Epithelia of IBD Patients.
Kawamoto A, Nagata S, Anzai S, Takahashi J, Kawai M, Hama M, Nogawa D, Yamamoto K, Kuno R, Suzuki K, Shimizu H, Hiraguri Y, Yui S, Oshima S, Tsuchiya K, Nakamura T, Ohtsuka K, Kitagawa M, Okamoto R, Watanabe M.
J Crohns Colitis. 2019 Mar 30;13(4):495-509. doi: 10.1093/ecco-jcc/jjy180.
https://pubmed.ncbi.nlm.nih.gov/30395194/

The fatty-acid amide hydrolase inhibitor URB597 inhibits MICA/B shedding.
Sekiba K, Otsuka M, Seimiya T, Tanaka E, Funato K, Miyakawa Y, Koike K.
Sci Rep. 2020 Sep 23;10(1):15556. doi: 10.1038/s41598-020-72688-y.
https://pubmed.ncbi.nlm.nih.gov/32968163/

PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA.
Yano K, Takahashi RU, Shiotani B, Abe J, Shidooka T, Sudo Y, Yamamoto Y, Kan S, Sakagami H, Tahara H.
J Biol Chem. 2021 Jul;297(1):100882. doi: 10.1016/j.jbc.2021.100882. Epub 2021 Jun 16.
https://pubmed.ncbi.nlm.nih.gov/34144037/

(-)‑Epigallocatechin‑3‑O‑gallate upregulates the expression levels of miR‑6757‑3p, a suppressor of fibrosis‑related gene expression, in extracellular vesicles derived from human umbilical vein endothelial cells.
Murata M, Marugame Y, Morozumi M, Murata K, Kumazoe M, Fujimura Y, Tachibana H.
Biomed Rep. 2023 Jan 23;18(3):19. doi: 10.3892/br.2023.1601. eCollection 2023 Mar.
https://pubmed.ncbi.nlm.nih.gov/36776784/

miR-515-5p suppresses trophoblast cell invasion and proliferation through XIAP regulation in preeclampsia.
Nunode M, Hayashi M, Nagayasu Y, Sawada M, Nakamura M, Sano T, Fujita D, Ohmichi M.
Mol Cell Endocrinol. 2023 Jan 1;559:111779. doi: 10.1016/j.mce.2022.111779. Epub 2022 Sep 22.
https://pubmed.ncbi.nlm.nih.gov/36155776/

Differences in circulating obesity-related microRNAs in Austrian and Japanese men: A two-country cohort analysis
Ichiro Wakabayashi , Yoko Sotoda, Klaus Groschner, Peter P Rainer, Harald Sourij
Metabol Open. 2022 Aug 17;15:100206.
https://pubmed.ncbi.nlm.nih.gov/36065413/

Investigation of umbilical cord serum miRNAs associated with childhood obesity: A pilot study from a birth cohort study.
Takatani R, Yoshioka Y, Takahashi T, Watanabe M, Hisada A, Yamamoto M, Sakurai K, Takatani T, Shimojo N, Hamada H, Ochiya T, Mori C.
J Diabetes Investig. 2022 Jun 2.
https://pubmed.ncbi.nlm.nih.gov/35653294/

Linderapyrone: A Wnt signal inhibitor isolated from Lindera umbellate
Takahiro Matsumoto, Takahiro Kitagawa, Daisuke Imahori, Atsushi Matsuzaki, Youhei Saito, Tomoe Ohta, Tatsusada Yoshida, Yuji Nakayama, Eishi Ashihara, Tetsushi Watanabe
Bioorg Med Chem Lett. 2021 Aug 1;45:128161.
https://pubmed.ncbi.nlm.nih.gov/34062253/

Hypoxia-induced nuclear translocation of β-catenin in the healing process of frostbite
Shotaro Isozaki,Hiroki Tanaka,Kie Horioka,Hiroaki Konishi,Shin Kashima,Shuhei Takauji,Mikihiro Fujiya,Henrik Druid
Biochim Biophys Acta Mol Basis Dis.2022 Jun 1;1868(6):166385.
https://pubmed.ncbi.nlm.nih.gov/35292361/

Zinc ions negatively regulate proapoptotic signaling in cells expressing oncogenic mutant Ras.
Hironori Edamatsu
BioMetals. 2022 Apr;35(2):349-362.
https://pubmed.ncbi.nlm.nih.gov/35212861/

S100A8/A9 Induced by Interaction with Macrophages in Esophageal Squamous Cell Carcinoma Promotes the Migration and Invasion of Cancer Cells via Akt and p38 MAPK Pathways.
Tanigawa K, Tsukamoto S, Koma YI, Kitamura Y, Urakami S, Shimizu M, Fujikawa M, Kodama T, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.
Am J Pathol. 2022 Mar;192(3):536-552.
https://pubmed.ncbi.nlm.nih.gov/34954212/

miR-216a-targeting theranostic　nanoparticles promote proliferation of insulin-secreting cells in type 1 diabetes animal model
Wang P, Liu Q, Zhao H, Bishop JO, Zhou G, Olson LK, Moore A
Sci Rep. 2020 Mar 24;10(1):5302. doi: 10.1038/s41598-020-62269-4
https://www.ncbi.nlm.nih.gov/pubmed/32210316

Concomitant Nrf2- and ATF4-Activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes
Junsei Mimura, Atsushi Inose-Maruyama, Shusuke Taniuchi, Kunio Kosaka, Hidemi Yoshida, Hiromi Yamazaki, Shuya Kasai, Nobuhiko Harada, Randal J. Kaufman, Seiichi Oyadomari and Ken Itoh
Int. J. Mol. Sci. 2019, 20(7), 1706; doi:10.3390/ijms20071706
https://www.ncbi.nlm.nih.gov/pubmed/30959808

Role of S1P/S1PR3 axis in release of CCL20 from human bronchial epithelial cells.
Kawa Y, Nagano T, Yoshizaki A, Dokuni R, Katsurada M, Terashita T, Yasuda Y, Umezawa K, Yamamoto M, Kamiryo H, Kobayashi K, Nishimura Y.
PLoS One. 2018 Sep 7;13(9):e0203211
https://www.ncbi.nlm.nih.gov/pubmed/30192865

ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells.
Yamagami M, Otsuka M, Kishikawa T, Sekiba K, Seimiya T, Tanaka E, Suzuki T, Ishibashi R, Ohno M, Koike K.
NPJ Aging Mech Dis. 2018 Nov 15;4:11
https://www.ncbi.nlm.nih.gov/pubmed/30455980

Dectin-2 Deficiency Modulates Th1 Differentiation and Improves Wound Healing After Myocardial Infarction. Yan X, Zhang H, Fan Q, Hu J, Tao R, Chen Q, Iwakura Y, Shen W, Lu L, Zhang Q, Zhang R. Circ Res. 2017 Mar 31;120(7):1116-1129.
https://www.ncbi.nlm.nih.gov/pubmed/28193608

The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure.
Ono T, Kamimura N, Matsuhashi T, Nagai T, Nishiyama T, Endo J, Hishiki T, Nakanishi T, Shimizu N, Tanaka H, Ohta S, Suematsu M, Ieda M, Sano M, Fukuda K, Kaneda R.
Sci Rep. 2017 Jan 4;7:39752.
https://www.ncbi.nlm.nih.gov/pubmed/28051130

Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-κB Signaling Pathway.
Ohtsu N, Nakatani Y, Yamashita D, Ohue S, Ohnishi T, Kondo T.
Cancer Res. 2016 Jan 1;76(1):171-81.
https://www.ncbi.nlm.nih.gov/pubmed/26677976

ΔNp63α induces quiescence and downregulates the BRCA1 pathway in estrogen receptor-positive luminal breast cancer cell line MCF7 but not in other breast cancer cell lines.
Amin R, Morita-Fujimura Y, Tawarayama H, Semba K, Chiba N, Fukumoto M, Ikawa S.
Mol Oncol. 2015 Nov 24. pii: S1574-7891(15)00208-2.
http://www.ncbi.nlm.nih.gov/pubmed/26704768

Interferon-β Mediates Signaling Pathways Uniquely Regulated in Hepatic Stellate Cells and Attenuates the Progression of Hepatic Fibrosis in a Dietary Mouse Model.
Shimozono R, Nishimura K, Akiyama H, Funamoto S, Izawa A, Sai T, Kunita K, Kainoh M, Suzuki T, Kawada N.
J Interferon Cytokine Res. 2015 Jun;35(6):464-73.
http://www.ncbi.nlm.nih.gov/pubmed/25715168

Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart.
Matsuhashi T, Hishiki T, Zhou H, Ono T, Kaneda R, Iso T, Yamaguchi A, Endo J, Katsumata Y, Atsushi A, Yamamoto T, Shirakawa K, Yan X, Shinmura K, Suematsu M, Fukuda K, Sano M.
J Mol Cell Cardiol. 2015 May;82:116-24.
http://www.ncbi.nlm.nih.gov/pubmed/25744081

MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis.
Katsura A, Morishita A, Iwama H, Tani J, Sakamoto T, Tatsuta M, Toyota Y, Fujita K, Kato K, Maeda E, Nomura T, Miyoshi H, Yoneyama H, Himoto T, Fujiwara S, Kobara H, Mori H, Niki T, Ono M, Hirashima M, Masaki T.
Int J Mol Med. 2015 Apr;35(4):877-84.
http://www.ncbi.nlm.nih.gov/pubmed/25672270

Transcriptional program of Kpna2/Importin-α2 regulates cellular differentiation-coupled circadian clock development in mammalian cells.
Umemura Y, Koike N, Matsumoto T, Yoo SH, Chen Z, Yasuhara N, Takahashi JS, Yagita K.
Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):E5039-48.
http://www.ncbi.nlm.nih.gov/pubmed/25389311

microRNA regulation of endothelin-1 mRNA in renal collecting duct cells.
Jacobs ME, Jeffers LA, Welch AK, Wingo CS, Cain BD.
Life Sci. 2014 Nov 24;118(2):195-9.
http://www.ncbi.nlm.nih.gov/pubmed/24632479

Distinct microRNA expression profiles in mouse renal cortical tissue after 177Lu-octreotate administration.
Schuler E, Parris TZ, Helou K, Forssell-Aronsson E.
PLoS One. 2014 Nov 11;9(11):e112645.
http://www.ncbi.nlm.nih.gov/pubmed/25386939

Crosstalk between the Rb Pathway and AKT Signaling Forms a Quiescence-Senescence Switch.
Imai Y, Takahashi A, Hanyu A, Hori S, Sato S, Naka K, Hirao A, Ohtani N, Hara E.
Cell Rep. 2014 Apr 10;7(1):194-207.
http://www.ncbi.nlm.nih.gov/pubmed/24703840

miR-192 Induces G2/M Growth Arrest in Aristolochic Acid Nephropathy.
Jenkins RH, Davies LC, Taylor PR, Akiyama H, Cumbes B, Beltrami C, Carrington CP, Phillips AO, Bowen T, Fraser DJ.
Am J Pathol. 2014 Apr;184(4):996-1009.
http://www.ncbi.nlm.nih.gov/pubmed/24508230

Apoptotic response through a high mobility box 1 protein-dependent mechanism in LPS/GalN-induced mouse liver failure and glycyrrhizin-mediated inhibition.
Kuroda N, Inoue K, Ikeda T, Hara Y, Wake K, Sato T.
PLoS One. 2014 Apr 1;9(4):e92884.
https://www.ncbi.nlm.nih.gov/pubmed/24690901

Myostatin signaling regulates Akt activity via the regulation of miR-486 expression.
Hitachi K, Nakatani M, Tsuchida K.
Int J Biochem Cell Biol. 2014 Feb;47:93-103.
http://www.ncbi.nlm.nih.gov/pubmed/24342526

Deficiency of NOX1/nicotinamide adenine dinucleotide phosphate, reduced form oxidase leads to pulmonary vascular remodeling.
Iwata K, Ikami K, Matsuno K, Yamashita T, Shiba D, Ibi M, Matsumoto M, Katsuyama M, Cui W, Zhang J, Zhu K, Takei N, Kokai Y, Ohneda O, Yokoyama T, Yabe-Nishimura C.
Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):110-9.
http://www.ncbi.nlm.nih.gov/pubmed/24233492

Expression profiling of ETO2-regulated miRNAs in erythroid cells: Possible influence on miRNA abundance. Fujiwara T, Okitsu Y, Katsuoka Y, Fukuhara N, Onishi Y, Ishizawa K, Harigae H. FEBS Open Bio. 2013 Oct 11;3:428-32.
http://www.ncbi.nlm.nih.gov/pubmed/24251106

Knockdown of human TCF4 affects multiple signaling pathways involved in cell survival, epithelial to mesenchymal transition and neuronal differentiation.
Forrest MP, Waite AJ, Martin-Rendon E, Blake DJ.
PLoS One. 2013 Aug 23;8(8):e73169.
http://www.ncbi.nlm.nih.gov/pubmed/24058414

MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis.
Ogawa T, Enomoto M, Fujii H, Sekiya Y, Yoshizato K, Ikeda K, Kawada N.
Gut. 2012 Nov;61(11):1600-9.
http://www.ncbi.nlm.nih.gov/pubmed/22267590

Gene expression analysis using a high-resolution DNA microarray of peripheral whole blood immediately before and after leukocytapheresis for rheumatoid arthritis.
Kusaoi M, Yamaji K, Murayama G, Yasui M, Yamada R, Hishinuma R, Nemoto T, Hohtatsu K, Kageyama M, Kawamoto T, Sugimoto K, Sekiya F, Kon T, Ogasawara M, Kempe K, Tsuda H, Takasaki Y.
Ther Apher Dial. 2012 Oct;16(5):456-66.
http://www.ncbi.nlm.nih.gov/pubmed/23046371

Synthesis and biological properties of highly sequence-specific-alkylating N-methylpyrrole-N-methylimidazole polyamide conjugates.
Kashiwazaki G, Bando T, Yoshidome T, Masui S, Takagaki T, Hashiya K, Pandian GN, Yasuoka J, Akiyoshi K, Sugiyama H.
J Med Chem. 2012 Mar 8;55(5):2057-66.
http://www.ncbi.nlm.nih.gov/pubmed/22309169

Different responses to oxidized low-density lipoproteins in human polarized macrophages.
Hirose K, Iwabuchi K, Shimada K, Kiyanagi T, Iwahara C, Nakayama H, Daida H.
Lipids Health Dis. 2011 Jan 4;10:1
http://www.ncbi.nlm.nih.gov/pubmed/21199582

OGFOD1, a member of the 2-oxoglutarate and iron dependent dioxygenase family, functions in ischemic signaling.
Saito K, Adachi N, Koyama H, Matsushita M.
FEBS Lett. 2010 Aug 4;584(15):3340-7.
http://www.ncbi.nlm.nih.gov/pubmed/20579638

The microRNA miR-696 regulates PGC-1{alpha} in mouse skeletal muscle in response to physical activity.
Aoi W, Naito Y, Mizushima K, Takanami Y, Kawai Y, Ichikawa H, Yoshikawa T.
Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E799-806
http://www.ncbi.nlm.nih.gov/pubmed/20086200

Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart.
Endo J, Sano M, Katayama T, Hishiki T, Shinmura K, Morizane S, Matsuhashi T, Katsumata Y, Zhang Y, Ito H, Nagahata Y, Marchitti S, Nishimaki K, Wolf AM, Nakanishi H, Hattori F, Vasiliou V, Adachi T, Ohsawa I, Taguchi R, Hirabayashi Y, Ohta S, Suematsu M, Ogawa S, Fukuda K.
Circ Res. 2009 Nov 20;105(11):1118-27.
http://www.ncbi.nlm.nih.gov/pubmed/19815821