論文
(3)マイクロRNAの解析

Relationship between circulating mitochondrial DNA and microRNA in patients with major depression.
Haruhiko Ogata, Koichiro Higasa, Yuki Kageyama, Hidetoshi Tahara, Akira Shimamoto, Yoshiteru Takekita, Yosuke Koshikawa, Shinpei Nonen, Tadafumi Kato, Toshihiko Kinoshita, Masaki Kato
J Affect Disord. 2023 Oct 15:339:538-546. doi: 10.1016/j.jad.2023.07.073. Epub 2023 Jul 17.

Multiple Pre-Treatment miRNAs Levels in Untreated Major Depressive Disorder Patients Predict Early Response to Antidepressants and Interact with Key Pathways.
Masaki Kato, Haruhiko Ogata, Hidetoshi Tahara, Akira Shimamoto, Yoshiteru Takekita, Yosuke Koshikawa, Keiichiro Nishida, Shinpei Nonen, Koichiro Higasa, Toshihiko Kinoshita
Int J Mol Sci. 2022 Mar 31;23(7):3873. doi: 10.3390/ijms23073873.

Changes in Multiple microRNA Levels with Antidepressant Treatment Are Associated with Remission and Interact with Key Pathways: A Comprehensive microRNA Analysis.
Toshiya Funatsuki, Haruhiko Ogata, Hidetoshi Tahara, Akira Shimamoto, Yoshiteru Takekita, Yosuke Koshikawa, Shinpei Nonen, Koichiro Higasa, Toshihiko Kinoshita, Masaki Kato
Int J Mol Sci. 2023 Jul 30;24(15):12199. doi: 10.3390/ijms241512199.

Global, cancer-specific microRNA cluster hypomethylation was functionally associated with the development of non-B non-C hepatocellular carcinoma.
Nojima M, Matsui T, Tamori A, Kubo S, Shirabe K, Kimura K, Shimada M, Utsunomiya T, Kondo Y, Iio E, Naito Y, Ochiya T, Tanaka Y.
Mol Cancer. 2016 Apr 30;15(1):31.
https://pubmed.ncbi.nlm.nih.gov/27137948/

Lung regeneration with rat fetal lung implantation and promotion of alveolar stem cell differentiation by corticosteroids
Daisuke Matsumoto, Hiroaki Toba, Koichiro Kenzaki, Shoji Sakiyama, Shinichi Sakamoto,Mika Takashima, Naoya Kawakita, Hiromitsu Takizawa
Regenerative Therapy. 2023 Sep 14;24:426-433.
https://pubmed.ncbi.nlm.nih.gov/37744680/

K63-linked polyubiquitination of LGP2 by Riplet regulates RIG-I-dependent innate immune response.
Kouwaki T, Nishimura T, Wang G, Nakagawa R, Oshiumi H.
EMBO Rep. 2023 Feb 6;24(2):e54844.
https://pubmed.ncbi.nlm.nih.gov/36515138/

Comparison of Characterization in Two-Dimensional and Three-Dimensional Canine Mammary Gland Tumor Cell Models.
Osaki T, Sunden Y, Warita K, Okamoto Y.
Yonago Acta Med. 2023 Feb 20;66(1):7-18.
https://pubmed.ncbi.nlm.nih.gov/36811028/

Oxygen-Glucose Deprived Peripheral Blood Mononuclear Cells Protect Against Ischemic Stroke.
Otsu Y, Hatakeyama M, Kanayama T, Akiyama N, Ninomiya I, Omae K, Kato T, Onodera O, Fukushima M, Shimohata T, Kanazawa M.
Neurotherapeutics. 2023 Jun 19.
https://pubmed.ncbi.nlm.nih.gov/37335500/

Oxygen-Glucose Deprived Peripheral Blood Mononuclear Cells Protect Against Ischemic Stroke.
Otsu Y, Hatakeyama M, Kanayama T, Akiyama N, Ninomiya I, Omae K, Kato T, Onodera O, Fukushima M, Shimohata T, Kanazawa M.
Neurotherapeutics. 2023 Jun 19. doi: 10.1007/s13311-023-01398-w. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/37335500/

ΔNp63α induces quiescence and downregulates the BRCA1 pathway in estrogen receptor-positive luminal breast cancer cell line MCF7 but not in other breast cancer cell lines.
Amin R, Morita-Fujimura Y, Tawarayama H, Semba K, Chiba N, Fukumoto M, Ikawa S.
Mol Oncol. 2016 Apr;10(4):575-93. doi: 10.1016/j.molonc.2015.11.009. Epub 2015 Nov 24.
https://pubmed.ncbi.nlm.nih.gov/26704768/

Mechanism of gemcitabine-induced suppression of human cholangiocellular carcinoma cell growth.
Toyota Y, Iwama H, Kato K, Tani J, Katsura A, Miyata M, Fujiwara S, Fujita K, Sakamoto T, Fujimori T, Okura R, Kobayashi K, Tadokoro T, Mimura S, Nomura T, Miyoshi H, Morishita A, Kamada H, Yoneyama H, Okano K, Suzuki Y, Masaki T.
Int J Oncol. 2015 Oct;47(4):1293-302. doi: 10.3892/ijo.2015.3118. Epub 2015 Aug 7.
https://pubmed.ncbi.nlm.nih.gov/26252371/

Prognostic relevance of miR-137 in patients with hepatocellular carcinoma.
Sakabe T, Azumi J, Umekita Y, Toriguchi K, Hatano E, Hirooka Y, Shiota G.
Liver Int. 2017 Feb;37(2):271-279. doi: 10.1111/liv.13213. Epub 2016 Aug 16.
https://pubmed.ncbi.nlm.nih.gov/27473646/

A tissue microRNA signature that predicts the prognosis of breast cancer in young women.
Hironaka-Mitsuhashi A, Matsuzaki J, Takahashi RU, Yoshida M, Nezu Y, Yamamoto Y, Shiino S, Kinoshita T, Ushijima T, Hiraoka N, Shimizu C, Tamura K, Ochiya T.
PLoS One. 2017 Nov 15;12(11):e0187638. doi: 10.1371/journal.pone.0187638. eCollection 2017.
https://pubmed.ncbi.nlm.nih.gov/29141042/

Graft-Versus-Host Disease Amelioration by Human Bone Marrow Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles Is Associated with Peripheral Preservation of Naive T Cell Populations.
Fujii S, Miura Y, Fujishiro A, Shindo T, Shimazu Y, Hirai H, Tahara H, Takaori-Kondo A, Ichinohe T, Maekawa T.
Stem Cells. 2018 Mar;36(3):434-445. doi: 10.1002/stem.2759. Epub 2017 Dec 27.
https://pubmed.ncbi.nlm.nih.gov/29239062/

The Interaction Between Long Non-coding RNA HULC and MicroRNA-622 via Transfer by Extracellular Vesicles Regulates Cell Invasion and Migration in Human Pancreatic Cancer.
Takahashi K, Koyama K, Ota Y, Iwamoto H, Yamakita K, Fujii S, Kitano Y.
Front Oncol. 2020 Jun 23;10:1013. doi: 10.3389/fonc.2020.01013. eCollection 2020.
https://pubmed.ncbi.nlm.nih.gov/32656089/

Nicotine Changes the microRNA Profile to Regulate the FOXO Memory Program of CD8+ T Cells in Rheumatoid Arthritis.
Wasén C, Ospelt C, Camponeschi A, Erlandsson MC, Andersson KME, Silfverswärd ST, Gay S, Bokarewa MI.
Front Immunol. 2020 Jul 14;11:1474. doi: 10.3389/fimmu.2020.01474. eCollection 2020.
https://pubmed.ncbi.nlm.nih.gov/32765511/

Recruitment of miR-8080 by luteolin inhibits androgen receptor splice variant 7 expression in castration-resistant prostate cancer.
Naiki-Ito A, Naiki T, Kato H, Iida K, Etani T, Nagayasu Y, Suzuki S, Yamashita Y, Inaguma S, Onishi M, Tanaka Y, Yasui T, Takahashi S.
Carcinogenesis. 2020 Aug 12;41(8):1145-1157. doi: 10.1093/carcin/bgz193.
https://pubmed.ncbi.nlm.nih.gov/31805186/

Suppression of intrahepatic cholangiocarcinoma cell growth by SKI via upregulation of the CDK inhibitor p21.
Kawamura E, Matsubara T, Daikoku A, Deguchi S, Kinoshita M, Yuasa H, Urushima H, Odagiri N, Motoyama H, Kotani K, Kozuka R, Hagihara A, Fujii H, Uchida-Kobayashi S, Tanaka S, Takemura S, Iwaisako K, Enomoto M, Taguchi YH, Tamori A, Kubo S, Ikeda K, Kawada N.
FEBS Open Bio. 2022 Dec;12(12):2122-2135. doi: 10.1002/2211-5463.13489. Epub 2022 Sep 26.
https://pubmed.ncbi.nlm.nih.gov/36114826/

Effect of Lenvatinib treatment on the cell cycle and microRNA profile in hepatocellular carcinoma cells.
Nakahara M, Fujihara S, Iwama H, Takuma K, Oura K, Tadokoro T, Fujita K, Tani J, Morishita A, Kobara H, Himoto T, Masaki T.
Biomed Rep. 2022 Aug 3;17(4):78. doi: 10.3892/br.2022.1561. eCollection 2022 Oct.
https://pubmed.ncbi.nlm.nih.gov/36158319/

Serum-derived exosomal miR-125a-3p predicts the response to anti-programmed cell death-1/programmed cell death-ligand 1 monotherapy in patients with non-small cell lung cancer.
Hisakane K, Seike M, Sugano T, Matsuda K, Kashiwada T, Nakamichi S, Matsumoto M, Miyanaga A, Noro R, Kubota K, Gemma A.
Gene. 2023 Mar 20;857:147177.
https://pubmed.ncbi.nlm.nih.gov/36623674/

Multiple Pre-Treatment miRNAs Levels in Untreated Major Depressive Disorder Patients Predict Early Response to Antidepressants and Interact with Key Pathways
Masaki Kato, Haruhiko Ogata, Hidetoshi Tahara, Akira Shimamoto, Yoshiteru Takekita, Yosuke Koshikawa, Keiichiro Nishida, Shinpei Nonen, Koichiro Higasa, Toshihiko Kinoshita
Int J Mol Sci. 2022 Mar 31;23(7):3873.
https://pubmed.ncbi.nlm.nih.gov/35409234/

Antiviral proinflammatory phenotype of monocytes in anti-MDA5 antibody-associated interstitial lung disease
Takahisa Gono, Yuka Okazaki, Masataka Kuwana.
Rheumatology (Oxford). 2022 Feb 2;61(2):806-814.
https://pubmed.ncbi.nlm.nih.gov/33890985/

Evaluating the Effect of Lenvatinib on Sorafenib-Resistant Hepatocellular Carcinoma Cells.
Shi T, Iwama H, Fujita K, Kobara H, Nishiyama N, Fujihara S, Goda Y, Yoneyama H, Morishita A, Tani J, Yamada M, Nakahara M, Takuma K, Masaki T.
Int J Mol Sci. 2021 Dec 2;22(23):13071.
https://pubmed.ncbi.nlm.nih.gov/34884875/

Hepatocellular Carcinoma-associated microRNAs Induced by Hepatoma-derived Growth Factor Stimulation
Hirayuki Enomoto , Hideji Nakamura , Hiroki Nishikawa , Takashi Nishimura , Yoshinori Iwata , Shuhei Nishiguchi , Hiroko Iijima
In Vivo. 2020 Sep-Oct;34(5):2297-2301.
https://pubmed.ncbi.nlm.nih.gov/32871753/

Gut commensals suppress interleukin-2 production through microRNA-200/BCL11B and microRNA-200/ETS-1 axes in lamina propria leukocytes of murine large intestine.
Ohsaka F, Karatsu Y, Kadota Y, Tochio T, Takemura N, Sonoyama K.
Biochem Biophys Res Commun. 2021 Jan 1;534:808-814.
https://pubmed.ncbi.nlm.nih.gov/33162030/

Dementia subtype prediction models constructed by penalized regression methods for multiclass classification using serum microRNA expression data
Yuya Asanomi, Daichi Shigemizu, Shintaro Akiyama, Takashi Sakurai, Kouichi Ozaki,
Takahiro Ochiya, Shumpei Niida
Scientific Reports volume 11, Article number: 20947 (2021)
https://pubmed.ncbi.nlm.nih.gov/34686734/

MiR-199-3p enhances muscle regeneration and ameliorates aged muscle and muscular dystrophy
Masashi Fukuoka, Hiromi Fujita, Kosumo Numao, Yasuko Nakamura, Hideo Shimizu, Masayuki Sekiguchi, Hirohiko Hohjoh
Commun Biol. 2021 Mar 29;4(1):427.
https://pubmed.ncbi.nlm.nih.gov/33782502/

miRNA-1246 in extracellular vesicles secreted from metastatic tumor induces drug resistance in tumor endothelial cells
Chisaho Torii, Nako Maishi, Taisuke Kawamoto, Masahiro Morimoto, Kosuke Akiyama , Yusuke Yoshioka, Takashi Minami, Takuya Tsumita, Mohammad Towfik Alam, Takahiro Ochiya, Yasuhiro Hida, Kyoko Hida
Sci Rep.2021 Jul 5;11(1):13502.
https://pubmed.ncbi.nlm.nih.gov/34226586/

Co-continuous structural effect of size-controlled macro-porous glass membrane on extracellular vesicle collection for the analysis of miRNA
Hiroshi Yukawa, Shuji Yamazaki, Keita Aoki, Kengo Muto, Naoto Kihara, Kazuhide Sato, Daisuke Onoshima, Takahiro Ochiya, Yasuhito Tanaka, Yoshinobu Baba
Sci Rep.2021 Apr 21;11(1):8672.
https://pubmed.ncbi.nlm.nih.gov/33883603/

Extracellular vesicles containing miR-146a-5p secreted by bone marrow mesenchymal cells activate hepatocytic progenitors in regenerating rat livers
Norihisa Ichinohe, Masayuki Ishii, Naoki Tanimizu, Toru Mizuguchi, Yusuke Yoshioka, Takahiro Ochiya, Hiromu Suzuki, Toshihiro Mitaka
Stem Cell Research & Therapy (2021) 12:312.
https://pubmed.ncbi.nlm.nih.gov/34051870/

Galectin-9 suppresses the tumor growth of colon cancer in vitro and in vivo
Asahiro Morishita, Kei Nomura, Joji Tani, Koji Fujita, Hisakazu Iwama, Kei Takuma, Mai Nakahara, Tomoko Tadokoro, Kyoko Oura, Taiga Chiyo, Shintaro Fujihara, Toshiro Niki, Mitsuomi Hirashima, Akira Nishiyama, Takashi Himoto, Tsutomu Masaki
Oncol Rep. 2021 Jun;45(6):105.
https://pubmed.ncbi.nlm.nih.gov/33907832/

MiR-199-3p enhances muscle regeneration and ameliorates aged muscle and muscular dystrophy
Masashi Fukuoka, Hiromi Fujita, Kosumo Numao, Yasuko Nakamura, Hideo Shimizu, Masayuki Sekiguchi & Hirohiko Hohjoh
Communications Biology volume 4, Article number: 427 (2021)
https://pubmed.ncbi.nlm.nih.gov/33782502/

Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss
Yuki Nakao, Takao Fukuda, Qunzhou Zhang, Terukazu Sanui, Takanori Shinjo, Xiaoxing Kou, Chider Chen, Dawei Liu, Yukari Watanabe, Chikako Hayashi, Hiroaki Yamato, Karen Yotsumoto, Urara Tanaka, Takaharu Taketomi, Takeshi Uchiumi, Anh D Le, Songtao Shi, Fusanori Nishimura
Acta Biomater.2020 Dec 24;S1742-7061(20)30769-8.doi: 10.1016/j.actbio.2020.12.046.
https://pubmed.ncbi.nlm.nih.gov/33359765/

Changes in circulating microRNA after recumbent isometric yoga practice by patients with myalgic encephalomyelitis/chronic fatigue syndrome: an explorative pilot study
Shu Takakura, Takakazu Oka, Nobuyuki Sudo
Biopsychosoc Med. 2019 Dec 2;13:29.
https://pubmed.ncbi.nlm.nih.gov/31827600

Blood levels of microRNAs associated with ischemic heart disease differ between Austrians and Japanese: a pilot study
Ichiro Wakabayashi, Ryoji Eguchi, Yoko Sotoda, Dirk von Lewinski, Harald Sourij, Takashi Daimon, Klaus Groschner, Peter P Rainer
Sci Rep. 2020 Aug 12;10(1):13628. doi: 10.1038/s41598-020-69332-0.
https://pubmed.ncbi.nlm.nih.gov/32788621

High-Throughput MicroRNA Profiling of Vitreoretinal Lymphoma: Vitreous and Serum MicroRNA Profiles Distinct From Uveitis
Teruumi Minezaki, Yoshihiko Usui, Masaki Asakage, Masakatsu Takanashi, Hiroyuki Shimizu, Naoya Nezu, Akitomo Narimatsu, Kinya Tsubota, Kazuhiko Umazume, Naoyuki Yamakawa, Masahiko Kuroda, Hiroshi Goto
J Clin Med. 2020 Jun 12;9(6):E1844. doi: 10.3390/jcm9061844
https://pubmed.ncbi.nlm.nih.gov/32545709

MicroRNA Expression Profiles of Neuron-Derived Extracellular Vesicles in Plasma From Patients With Amyotrophic Lateral Sclerosis
Masataka Katsu, Yuka Hama, Jun Utsumi, Ken Takashina, Hiroshi Yasumatsu, Fumiaki Mori, Koichi Wakabayashi, Mikio Shoji, Hidenao Sasaki
Neurosci Lett.2019 Aug 24;708:134176. doi: 10.1016/j.neulet.2019.03.048. Epub 2019 Jun 4.
https://pubmed.ncbi.nlm.nih.gov/31173847

MicroRNA profiles involved in trifluridine resistance.
Tsunekuni K, Konno M, Asai A, Koseki J, Kobunai T, Takechi T, Doki Y, Mori M, Ishii H.
Oncotarget. 2017 May 23;8(32):53017-53027. doi: 10.18632/oncotarget.18078. eCollection 2017 Aug 8.
https://www.ncbi.nlm.nih.gov/pubmed/28881790

MicroRNA miR-374, a potential radiosensitizer for carbon ion beam radiotherapy.
Baek SJ, Sato K, Nishida N, Koseki J, Azuma R, Kawamoto K, Konno M, Hayashi K, Satoh T, Doki Y, Mori M, Ishii H, Ogawa K.
Oncol Rep. 2016 Nov;36(5):2946-2950. doi: 10.3892/or.2016.5122. Epub 2016 Sep 22.
https://www.ncbi.nlm.nih.gov/pubmed/27665739

Relationships among erythrocyte-derived microRNAs in serum of healthy donors.
Wakabayashi I, Sotoda Y, Eguchi R.
Clin Chim Acta. 2020 Mar 30. pii: S0009-8981(20)30136-4. doi: 10.1016/j.cca.2020.03.034.
https://www.ncbi.nlm.nih.gov/pubmed/32240657

Exploration of Exosomal Micro RNA Biomarkers Related to Epithelial-to-Mesenchymal Transition in Pancreatic Cancer
Sonohara F, Yamada S, Takeda S, Hayashi M, Suenaga M, Sunagawa Y, Tashiro M, Takami H, Kanda M, Tanaka C, Kobayashi D, Nakayama G, Koike M, Fujiwara M, Kodera Y.
Anticancer Res. 2020 Apr;40(4):1843-1853. doi: 10.21873/anticanres.14138
https://www.ncbi.nlm.nih.gov/pubmed/32234872

Highly Sensitive Circulating MicroRNA Panel for Accurate Detection of Hepatocellular Carcinoma in Patients With Liver Disease.
Yamamoto Y, Kondo S, Matsuzaki J, Esaki M, Okusaka T, Shimada K, Murakami Y, Enomoto M, Tamori A, Kato K, Aoki Y, Takizawa S, Sakamoto H, Niida S, Takeshita F, Ochiya T
Hepatol Commun. 2019 Dec 19;4(2):284-297. doi: 10.1002/hep4.1451. eCollection 2020 Feb.
https://www.ncbi.nlm.nih.gov/pubmed/32025611

Peripheral neuropathy from paclitaxel: risk prediction by serum microRNAs.
Noda-Narita S, Shimomura A, Tanabe Y, Kawauchi J, Matsuzaki J, Takizawa S, Aoki Y, Shimizu C, Tamura K, Ochiya T
BMJ Support Palliat Care. 2020 Jan 14. pii: bmjspcare-2019-001900. doi: 10.1136/bmjspcare-2019-001900.
https://www.ncbi.nlm.nih.gov/pubmed/31937590

Brain metastasis-related microRNAs in patients with advanced breast cancer.
Sato J, Shimomura A, Kawauchi J, Matsuzaki J, Yamamoto Y, Takizawa S, Sakamoto H, Ohno M, Narita Y, Ochiya T, Tamura K.
PLoS One. 2019 Oct 11;14(10):e0221538. doi: 10.1371/journal.pone.0221538. eCollection 2019
https://www.ncbi.nlm.nih.gov/pubmed/31603918

Serum microRNA profile enables preoperative diagnosis of uterine leiomyosarcoma.
Yokoi A, Matsuzaki J, Yamamoto Y, Tate K, Yoneoka Y, Shimizu H, Uehara T, Ishikawa M, Takizawa S, Aoki Y, Kato K, Kato T, Ochiya T
Cancer Sci. 2019 Dec;110(12):3718-3726. doi: 10.1111/cas.14215. Epub 2019 Nov 16
https://www.ncbi.nlm.nih.gov/pubmed/31599471

Exosomal hsa-miR-933 in Gastric Juice as a Potential Biomarker for Functional Dyspepsia.
Tanaka F, Takashima S, Nadatani Y, Otani K, Hosomi S, Kamata N, Taira K, Nagami Y, Tanigawa T, Fukumoto S, Watanabe T, Murakami Y, Kawada N, Fujiwara Y.
Dig Dis Sci. 2020 Jan 23. doi: 10.1007/s10620-020-06096-7.
https://www.ncbi.nlm.nih.gov/pubmed/31974910

A miRNA-based diagnostic model predicts resectable lung cancer in humans with high accuracy.
Asakura K, Kadota T, Matsuzaki J, Yoshida Y, Yamamoto Y, Nakagawa K, Takizawa S, Aoki Y, Nakamura E, Miura J, Sakamoto H, Kato K, Watanabe S, Ochiya T
Commun Biol. 2020 Mar 19;3(1):134. doi: 10.1038/s42003-020-0863-y
https://www.ncbi.nlm.nih.gov/pubmed/32193503

Plasma microRNA profiles: identification of miR-1229-3p as a novel chemoresistant and prognostic biomarker in gastric cancer.
Nishibeppu K, Komatsu S, Imamura T, Kiuchi J, Kishimoto T, Arita T, Kosuga T, Konishi H, Kubota T, Shiozaki A, Fujiwara H, Okamoto K, Otsuji E
Sci Rep. 2020 Feb 21;10(1):3161. doi: 10.1038/s41598-020-59939-8
https://www.ncbi.nlm.nih.gov/pubmed/32081926

miR-216a-targeting theranostic nanoparticles promote proliferation of insulin-secreting cells in type 1 diabetes animal model
Wang P, Liu Q, Zhao H, Bishop JO, Zhou G, Olson LK, Moore A
Sci Rep. 2020 Mar 24;10(1):5302. doi: 10.1038/s41598-020-62269-4
https://www.ncbi.nlm.nih.gov/pubmed/32210316

Extracellular vesicles microRNA analysis in type 1 autoimmune pancreatitis: Increased expression of microRNA-21.
Nakamaru K, Tomiyama T, Kobayashi S, Ikemune M, Tsukuda S, Ito T, Tanaka T, Yamaguchi T, Ando Y, Ikeura T, Fukui T, Nishio A, Takaoka M, Uchida K, Leung PSC, Gershwin ME, Okazaki K
Pancreatology. 2020 Feb 21. pii: S1424-3903(20)30048-X. doi: 10.1016/j.pan.2020.02.012. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/32147308

MicroRNA-141-3p and microRNA-200a-3p regulate α-melanocyte stimulating hormone-stimulated melanogenesis by directly targeting microphthalmia-associated transcription factor..
Itoh T, Fukatani K, Nakashima A, Suzuki K.
Sci Rep. 2020 Feb 7;10(1):2149. doi: 10.1038/s41598-020-58911-w
https://www.ncbi.nlm.nih.gov/pubmed/32034251

Assessment of the Diagnostic Utility of Serum MicroRNA Classification in Patients With Diffuse Glioma.
Ohno M, Matsuzaki J, Kawauchi J, Aoki Y, Miura J, Takizawa S, Kato K, Sakamoto H, Matsushita Y, Takahashi M, Miyakita Y, Ichimura K, Narita Y, Ochiya T.
JAMA Netw Open. 2019 Dec 2;2(12):e1916953. doi: 10.1001/jamanetworkopen.2019.16953
https://www.ncbi.nlm.nih.gov/pubmed/31808923

Identification of serum microRNAs predicting the response of esophageal squamous-cell carcinoma to nivolumab.
Sudo K, Kato K, Matsuzaki J, Takizawa S, Aoki Y, Shoji H, Iwasa S, Honma Y, Takashima A, Sakamoto H6, Naka T, Sekine S, Boku N, Ochiya T.
Jpn J Clin Oncol. 2019 Oct 15. pii: hyz146. doi: 10.1093/jjco/hyz146
https://www.ncbi.nlm.nih.gov/pubmed/31612917

Supplemental Treatment for Huntington's Disease with miR-132 that Is Deficient in Huntington's Disease Brain.
Fukuoka M, Takahashi M, Fujita H, Chiyo T, Popiel HA, Watanabe S, Furuya H, Murata M, Wada K, Okada T, Nagai Y, Hohjoh H.
Mol Ther Nucleic Acids. 2018 Jun 1;11:79-90. doi: 10.1016/j.omtn.2018.01.007. Epub 2018 Feb 2
https://www.ncbi.nlm.nih.gov/pubmed/29858092

A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes.
Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, Nakayama R, Morioka H, Matsumoto M, Nakamura M, Kondo T, Kato K, Tsuchiya N, Kawai A, Ochiya T
Nat Commun. 2019 Mar 21;10(1):1299. doi: 10.1038/s41467-019-09143-8
https://www.ncbi.nlm.nih.gov/pubmed/?term=A+serum+microRNA+classifier+for+the+diagnosis+of

MicroRNA profiles during galectin-9-induced apoptosis of pancreatic cancer cells.
Okura R, Fujihara S, Iwama H, Morishita A, Chiyo T, Watanabe M, Hirose K, Kobayashi K, Fujimori T, Kato K, Kamada H, Kobara H, Mori H, Niki T, Hirashima M, Okano K, Suzuki Y, Masaki T.
Oncol Lett. 2018 Jan;15(1):407-414.
https://www.ncbi.nlm.nih.gov/pubmed/29387226

MicroRNA-8073: Tumor suppressor and potential therapeutic treatment.
Mizoguchi A, Takayama A, Arai T, Kawauchi J, Sudo H.
PLoS One. 2018 Dec 27;13(12):e0209750. doi: 10.1371/journal.pone.0209750. eCollection 2018.
https://www.ncbi.nlm.nih.gov/pubmed/30589909

Expression profile of miR-17/92 cluster is predictive of treatment response in rectal cancer.
Kral J, Korenkova V, Novosadova V, Langerova L, Schneiderova M, Liska V, Levy M, Veskrnova V, Spicak J, Opattova A, Jiraskova K, Vymetalkova V, Vodicka P, Slyskova J.
Carcinogenesis. 2018 Oct 1. doi: 10.1093/carcin/bgy100
https://www.ncbi.nlm.nih.gov/pubmed/30277504

A Panel of MicroRNA Signature as a Tool for Predicting Survival of Patients with Urothelial Carcinoma of the Bladder.
Inamoto T, Uehara H, Akao Y, Ibuki N, Komura K, Takahara K, Takai T, Uchimoto T, Saito K, Tanda N, Yoshikawa Y, Minami K, Hirano H, Nomi H, Kato R, Hayashi T, Azuma H.
Dis Markers. 2018 Jun 20;2018:5468672. doi: 10.1155/2018/5468672. eCollection 2018
https://www.ncbi.nlm.nih.gov/pubmed/30026881

Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis.
Kimura K, Hohjoh H, Fukuoka M, Sato W, Oki S, Tomi C, Yamaguchi H, Kondo T, Takahashi R, Yamamura T.
Nat Commun. 2018 Jan 2;9(1):17. doi: 10.1038/s41467-017-02406-2.
https://www.ncbi.nlm.nih.gov/pubmed/29295981

The angiotensin II type 1 receptor antagonist telmisartan inhibits cell proliferation and tumor growth of esophageal adenocarcinoma via the AMPKα/mTOR pathway in vitro and in vivo.
Fujihara S, Morishita A, Ogawa K, Tadokoro T, Chiyo T, Kato K, Kobara H, Mori H, Iwama H, Masaki T.
Oncotarget. 2017 Jan 31;8(5):8536-8549.
https://www.ncbi.nlm.nih.gov/pubmed/28052030

Cluster microRNAs miR-194 and miR-215 suppress the tumorigenicity of intestinal tumor organoids.
Nakaoka T, Saito Y, Shimamoto Y, Muramatsu T, Kimura M, Kanai Y, Saito H.
Cancer Sci. 2017 Jan 16
https://www.ncbi.nlm.nih.gov/pubmed/28092415

Repression of microRNA Function Mediates Inflammation-associated Colon Tumorigenesis.
Yoshikawa T, Wu J, Otsuka M, Kishikawa T, Suzuki N, Takata A, Ohno M, Ishibashi R, Yamagami M, Nakagawa R, Kato N, Miyazawa M, Han J, Koike K.
Gastroenterology. 2016 Nov 5. pii: S0016-5085(16)35322-7
https://www.ncbi.nlm.nih.gov/pubmed/27825961

Gene Signature-Based Development of ELISA Assays for Reproducible Qualification of Cultured Human Corneal Endothelial Cells.
Ueno M, Asada K, Toda M, Schlotzer-Schrehardt U, Nagata K, Montoya M, Sotozono C, Kinoshita S, Hamuro J.
Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4295-305.
https://www.ncbi.nlm.nih.gov/pubmed/27552407

Histone Deacetylase Inhibition in Prostate Cancer Triggers miR-320-Mediated Suppression of the Androgen Receptor.
Sato S, Katsushima K, Shinjo K, Hatanaka A, Ohka F, Suzuki S, Naiki-Ito A, Soga N, Takahashi S, Kondo Y.
Cancer Res. 2016 Jul 15;76(14):4192-204.
https://www.ncbi.nlm.nih.gov/pubmed/27216188

The anti-diabetic drug metformin inhibits pancreatic cancer cell proliferation in vitro and in vivo: Study of the microRNAs associated with the antitumor effect of metformin.
Oncol Rep. 2016 Mar;35(3):1582-92.
Kato K, Iwama H, Yamashita T, Kobayashi K, Fujihara S, Fujimori T, Kamada H, Kobara H, Masaki T.
https://www.ncbi.nlm.nih.gov/pubmed/26708419

Antitumor effect of metformin on cholangiocarcinoma: In vitro and in vivo studies.
Oncol Rep. 2015 Dec;34(6):2987-96.
Fujimori T, Kato K, Fujihara S, Iwama H, Yamashita T, Kobayashi K, Kamada H, Morishita A, Kobara H, Mori H, Okano K, Suzuki Y, Masaki T.
https://www.ncbi.nlm.nih.gov/pubmed/26398221

Differences in miRNA expression profiles between GIST and leiomyoma in human samples acquired by submucosal tunneling biopsy.
Fujita K, Kobara H, Mori H, Fujihara S, Chiyo T, Matsunaga T, Nishiyama N, Ayaki M, Yachida T, Morishita A, Fujiwara M, Okano K, Suzuki Y, Iwama H, Masaki T.
Endosc Int Open. 2015 Dec;3(6):E665-71
http://www.ncbi.nlm.nih.gov/pubmed/26716134

Galectin-9 suppresses cholangiocarcinoma cell proliferation by inducing apoptosis but not cell cycle arrest.
Kobayashi K, Morishita A, Iwama H, Fujita K, Okura R, Fujihara S, Yamashita T, Fujimori T, Kato K, Kamada H, Niki T, Hirashima M, Okano K, Suzuki Y, Masaki T.
Oncol Rep. 2015 Oct;34(4):1761-70.
https://www.ncbi.nlm.nih.gov/pubmed/26260906

miR-487b, miR-3963 and miR-6412 delay myogenic differentiation in mouse myoblast-derived C2C12 cells.
Katase N, Terada K, Suzuki T, Nishimatsu S, Nohno T.
BMC Cell Biol. 2015 Apr 30;16:13.
http://www.ncbi.nlm.nih.gov/pubmed/25925429

Galectin-9 suppresses the growth of hepatocellular carcinoma via apoptosis in vitro and in vivo.
Fujita K, Iwama H, Sakamoto T, Okura R, Kobayashi K, Takano J, Katsura A, Tatsuta M, Maeda E, Mimura S, Nomura T, Tani J, Miyoshi H, Morishita A, Yoneyama H, Yamana Y, Himoto T, Okano K, Suzuki Y, Niki T, Hirashima M, Masaki T.
Int J Oncol. 2015;46(6):2419-30.
https://www.ncbi.nlm.nih.gov/pubmed/25823465

MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis.
Katsura A, Morishita A, Iwama H, Tani J, Sakamoto T, Tatsuta M, Toyota Y, Fujita K, Kato K, Maeda E, Nomura T, Miyoshi H, Yoneyama H, Himoto T, Fujiwara S, Kobara H, Mori H, Niki T, Ono M, Hirashima M, Masaki T.
Int J Mol Med. 2015 Apr;35(4):877-84.
http://www.ncbi.nlm.nih.gov/pubmed/25672270

Identification of a MicroRNA Signature for the Diagnosis of Fibromyalgia.
Cerda-Olmedo G, Mena-Duran AV, Monsalve V, Oltra E.
PLoS One. 2015 Mar 24;10(3):e0121903.
http://www.ncbi.nlm.nih.gov/pubmed/25803872

Concurrent Targeting of KRAS and AKT by MiR-4689 Is a Novel Treatment Against Mutant KRAS Colorectal Cancer.
Hiraki M, Nishimura J, Takahashi H, Wu X, Takahashi Y, Miyo M, Nishida N, Uemura M, Hata T, Takemasa I, Mizushima T, Soh JW, Doki Y, Mori M, Yamamoto H.
Mol Ther Nucleic Acids. 2015 Mar 10;4:e231.
http://www.ncbi.nlm.nih.gov/pubmed/25756961

Involvement of miR-518c-5p to growth and metastasis in oral cancer.
Kinouchi M, Uchida D, Kuribayashi N, Tamatani T, Nagai H, Miyamoto Y.
PLoS One. 2014 Dec 23;9(12):e115936.
http://www.ncbi.nlm.nih.gov/pubmed/25536052

microRNA regulation of endothelin-1 mRNA in renal collecting duct cells.
Jacobs ME, Jeffers LA, Welch AK, Wingo CS, Cain BD.
Life Sci. 2014 Nov 24;118(2):195-9.
http://www.ncbi.nlm.nih.gov/pubmed/24632479

Distinct microRNA expression profiles in mouse renal cortical tissue after 177Lu-octreotate administration.
Schuler E, Parris TZ, Helou K, Forssell-Aronsson E.
PLoS One. 2014 Nov 11;9(11):e112645.
http://www.ncbi.nlm.nih.gov/pubmed/25386939

Decreased miR-26a Expression Correlates with the Progression of Podocyte Injury in Autoimmune Glomerulonephritis.
Ichii O, Otsuka-Kanazawa S, Horino T, Kimura J, Nakamura T, Matsumoto M, Toi M, Kon Y.
PLoS One. 2014 Oct 17;9(10):e110383.
http://www.ncbi.nlm.nih.gov/pubmed/25329154

MicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancer.
Hasegawa S, Eguchi H, Nagano H, Konno M, Tomimaru Y, Wada H, Hama N, Kawamoto K, Kobayashi S, Nishida N, Koseki J, Nishimura T, Gotoh N, Ohno S, Yabuta N, Nojima H, Mori M, Doki Y, Ishii H.
Br J Cancer. 2014 Oct 14;111(8):1572-80.
http://www.ncbi.nlm.nih.gov/pubmed/25117811

Silencing of microRNA-122 is an early event during hepatocarcinogenesis from non-alcoholic steatohepatitis.
Takaki Y, Saito Y, Takasugi A, Toshimitsu K, Yamada S, Muramatsu T, Kimura M, Sugiyama K, Suzuki H, Arai E, Ojima H, Kanai Y, Saito H.
Cancer Sci. 2014 Oct;105(10):1254-60.
http://www.ncbi.nlm.nih.gov/pubmed/25117675

Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA.
Kohno T, Tsuge M, Murakami E, Hiraga N, Abe H, Miki D, Imamura M, Ochi H, Hayes CN, Chayama K.
J Viral Hepat. 2014;21(9):e89-97.
http://www.ncbi.nlm.nih.gov/pubmed/24835118

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells.
Ono M, Kosaka N, Tominaga N, Yoshioka Y, Takeshita F, Takahashi RU, Yoshida M, Tsuda H, Tamura K, Ochiya T.
Sci Signal. 2014 Jul 1;7(332)
http://www.ncbi.nlm.nih.gov/pubmed/24985346

Inhibitors of enhancer of zeste homolog 2 (EZH2) activate tumor-suppressor microRNAs in human cancer cells.
Hibino S, Saito Y, Muramatsu T, Otani A, Kasai Y, Kimura M, Saito H.
Oncogenesis. 2014 May 26;3:e104.
http://www.ncbi.nlm.nih.gov/pubmed/24861464

miR-192 Induces G2/M Growth Arrest in Aristolochic Acid Nephropathy.
Jenkins RH, Davies LC, Taylor PR, Akiyama H, Cumbes B, Beltrami C, Carrington CP, Phillips AO, Bowen T, Fraser DJ.
Am J Pathol. 2014 Apr;184(4):996-1009.
http://www.ncbi.nlm.nih.gov/pubmed/24508230

Myostatin signaling regulates Akt activity via the regulation of miR-486 expression.
Hitachi K, Nakatani M, Tsuchida K.
Int J Biochem Cell Biol. 2014 Feb;47:93-103.
http://www.ncbi.nlm.nih.gov/pubmed/24342526

Downregulation of miR-15a due to LMP1 promotes cell proliferation and predicts poor prognosis in nasal NK/T-cell lymphoma.
Komabayashi Y, Kishibe K, Nagato T, Ueda S, Takahara M, Harabuchi Y.
Am J Hematol. 2014 Jan;89(1):25-33.
http://www.ncbi.nlm.nih.gov/pubmed/23963825

Role of aquaporin-5 in gallbladder carcinoma.
Sekine S, Shimada Y, Nagata T, Sawada S, Yoshioka I, Matsui K, Moriyama M, Omura T, Osawa S, Shibuya K, Hashimoto I, Watanabe T, Hojo S, Hori R, Okumura T, Yoshida T, Tsukada K.
Eur Surg Res. 2013;51(3-4):108-17.
http://www.ncbi.nlm.nih.gov/pubmed/24217644

B-cell malignancies in microRNA Eµ-miR-17~92 transgenic mice.
Sandhu SK, Fassan M, Volinia S, Lovat F, Balatti V, Pekarsky Y, Croce CM.
Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18208-13.
http://www.ncbi.nlm.nih.gov/pubmed/24145403

Expression profiling of ETO2-regulated miRNAs in erythroid cells: Possible influence on miRNA abundance.
Fujiwara T, Okitsu Y, Katsuoka Y, Fukuhara N, Onishi Y, Ishizawa K, Harigae H.
FEBS Open Bio. 2013 Oct 11;3:428-32.
http://www.ncbi.nlm.nih.gov/pubmed/24251106

The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice.
Ohno M, Shibata C, Kishikawa T, Yoshikawa T, Takata A, Kojima K, Akanuma M, Kang YJ, Yoshida H, Otsuka M, Koike K.
Sci Rep. 2013 Aug 30;3:2553.
http://www.ncbi.nlm.nih.gov/pubmed/23989853

Osteogenic differentiation capacity of human skeletal muscle-derived progenitor cells.
Oishi T, Uezumi A, Kanaji A, Yamamoto N, Yamaguchi A, Yamada H, Tsuchida K.
PLoS One. 2013;8(2):e56641.
http://www.ncbi.nlm.nih.gov/pubmed/23457598

MiR-1290 and its potential targets are associated with characteristics of estrogen receptor α-positive breast cancer.
Endo Y, Toyama T, Takahashi S, Yoshimoto N, Iwasa M, Asano T, Fujii Y, Yamashita H.
Endocr Relat Cancer. 2013 Feb 18;20(1):91-102.
http://www.ncbi.nlm.nih.gov/pubmed/23183268

Identification of miR-30d as a novel prognostic maker of prostate cancer.
Kobayashi N, Uemura H, Nagahama K, Okudela K, Furuya M, Ino Y, Ito Y, Hirano H, Inayama Y, Aoki I, Nagashima Y, Kubota Y, Ishiguro H.
Oncotarget. 2012 Nov;3(11):1455-71.
http://www.ncbi.nlm.nih.gov/pubmed/23231923

MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis.
Ogawa T, Enomoto M, Fujii H, Sekiya Y, Yoshizato K, Ikeda K, Kawada N.
Gut. 2012 Nov;61(11):1600-9. 
http://www.ncbi.nlm.nih.gov/pubmed/22267590

Clinical significance of miR-144-ZFX axis in disseminated tumour cells in bone marrow in gastric cancer cases.
Akiyoshi S, Fukagawa T, Ueo H, Ishibashi M, Takahashi Y, Fabbri M, Sasako M, Maehara Y, Mimori K, Mori M.
Br J Cancer. 2012 Oct 9;107(8):1345-53. 
http://www.ncbi.nlm.nih.gov/pubmed/22955854

Trastuzumab produces therapeutic actions by upregulating miR-26a and miR-30b in breast cancer cells.
Ichikawa T, Sato F, Terasawa K, Tsuchiya S, Toi M, Tsujimoto G, Shimizu K.
PLoS One. 2012;7(2):e31422. 
http://www.ncbi.nlm.nih.gov/pubmed/22384020

Unraveling the global microRNAome responses to ionizing radiation in human embryonic stem cells.
Sokolov MV, Panyutin IV, Neumann RD.
PLoS One. 2012;7(2):e31028. 
http://www.ncbi.nlm.nih.gov/pubmed/22347422

Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage.
Kuwabara Y, Ono K, Horie T, Nishi H, Nagao K, Kinoshita M, Watanabe S, Baba O, Kojima Y, Shizuta S, Imai M, Tamura T, Kita T, Kimura T.
Circ Cardiovasc Genet. 2011 Aug 1;4(4):446-54. 
http://www.ncbi.nlm.nih.gov/pubmed/21642241

miR-22 represses cancer progression by inducing cellular senescence.
Xu D, Takeshita F, Hino Y, Fukunaga S, Kudo Y, Tamaki A, Matsunaga J, Takahashi RU, Takata T, Shimamoto A, Ochiya T, Tahara H.
J Cell Biol. 2011 Apr 18;193(2):409-24.
http://www.ncbi.nlm.nih.gov/pubmed/21502362

Identification of altered MicroRNA expression patterns in synovial sarcoma.
Hisaoka M, Matsuyama A, Nagao Y, Luan L, Kuroda T, Akiyama H, Kondo S, Hashimoto H.
Genes Chromosomes Cancer. 2011 Mar;50(3):137-45. 
http://www.ncbi.nlm.nih.gov/pubmed/21213367

MicroRNA profile predicts recurrence after resection in patients with hepatocellular carcinoma within the Milan Criteria.
Sato F, Hatano E, Kitamura K, Myomoto A, Fujiwara T, Takizawa S, Tsuchiya S, Tsujimoto G, Uemoto S, Shimizu K.
PLoS One. 2011 Jan 27;6(1):e16435.
http://www.ncbi.nlm.nih.gov/pubmed/21298008

MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1).
Tsuchiya S, Fujiwara T, Sato F, Shimada Y, Tanaka E, Sakai Y, Shimizu K, Tsujimoto G.
J Biol Chem. 2011 Jan 7;286(1):420-8. 
http://www.ncbi.nlm.nih.gov/pubmed/21044961

The microRNA miR-696 regulates PGC-1{alpha} in mouse skeletal muscle in response to physical activity.
Aoi W, Naito Y, Mizushima K, Takanami Y, Kawai Y, Ichikawa H, Yoshikawa T.
Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E799-806
http://www.ncbi.nlm.nih.gov/pubmed/20086200