論文
(7) 免疫・感染関連 (immune system・infection)

miR-582-5p targets Skp1 and regulates NF-κB signaling-mediated inflammation.
Li R, Sano T, Mizokami A, Fukuda T, Shinjo T, Iwashita M, Yamashita A, Sanui T, Nakatsu Y, Sotomaru Y, Asano T, Kanematsu T, Nishimura F.
Arch Biochem Biophys. 2023 Jan 15;734:109501.
https://pubmed.ncbi.nlm.nih.gov/36592647/

Aging-Associated Extracellular Vesicles Contain Immune Regulatory microRNAs Alleviating Hyperinflammatory State and Immune Dysfunction in the Elderly
Hirotake Tsukamoto, Takahisa Kouwaki, Hiroyuki Oshiumi
iScience. 2020 Sep 1;23(9):101520.
https://pubmed.ncbi.nlm.nih.gov/32927264/

miR-451a levels rather than human papillomavirus vaccine administration is associated with the severity of murine experimental autoimmune encephalomyelitis
Momoka Nakashima, Kana Ishikawa, Aika Fugiwara, Kaiin Shu, Yoshimi Fukushima, Masaaki Okamoto, Hirotake Tsukamoto, Takahisa Kouwaki, Hiroyuki Oshiumi
Sci Rep.021 Apr 30;11(1):9369.
https://pubmed.ncbi.nlm.nih.gov/33931700/

Gut commensals suppress interleukin-2 production through microRNA-200/BCL11B and microRNA-200/ETS-1 axes in lamina propria leukocytes of murine large intestine.
Ohsaka F, Karatsu Y, Kadota Y, Tochio T, Takemura N, Sonoyama K.
Biochem Biophys Res Commun. 2021 Jan 1;534:808-814.
https://pubmed.ncbi.nlm.nih.gov/33162030/

Distinctive Tissue and Serum MicroRNA Profile of IgG4-Related Ophthalmic Disease and MALT Lymphoma.
Nezu N, Usui Y, Asakage M, Shimizu H, Tsubota K, Narimatsu A, Umazume K, Yamakawa N, Ohno SI, Takanashi M, Kuroda M, Goto H
J Clin Med. 2020 Aug 5;9(8):2530.
https://pubmed.ncbi.nlm.nih.gov/32764512/

Interferon-induced protein with tetratricopeptide repeats 3 may be a key factor in primary biliary cholangitis
Sasaki M, Sato Y, Nakanuma Y.
Sci Rep 2021 Jun 1;11(1):11413.
https://pubmed.ncbi.nlm.nih.gov/34075171/

Differential bronchial epithelial response regulated by deltaNp63: a functional understanding of the epithelial shedding found in asthma.
Kubo T, Tsujiwaki M, Hirohashi Y, Tsukahara T, Kanaseki T, Nakatsugawa M, Hasegawa T, Torigoe T.
Lab Invest. 2019 Feb;99(2):158-168.
https://pubmed.ncbi.nlm.nih.gov/30254318/

Attenuation of the Innate Immune Response against Viral Infection Due to ZNF598-Promoted Binding of FAT10 to RIG-I
Guanming Wang,Takahisa Kouwaki, Masaaki Okamoto,and Hiroyuki Oshiumi
Cell Rep.2019 Aug 20;28(8):1961-1970.e4.
https://pubmed.ncbi.nlm.nih.gov/31433974/

Aging-Associated Extracellular Vesicles Contain Immune Regulatory microRNAs Alleviating Hyperinflammatory State and Immune Dysfunction in the Elderly
Hirotake Tsukamoto, Takahisa Kouwaki, and Hiroyuki Oshiumi
iScience. 2020 Sep 25; 23(9): 101520.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495115/

Development of a Novel Site-Specific Pegylated Interferon Beta for Antiviral Therapy of Chronic Hepatitis B Virus.
Tsuge M, Uchida T, Hiraga N, Kan H, Makokha GN, Abe-Chayama H, Miki D, Imamura M, Ochi H, Hayes CN, Shimozono R, Iwamura T, Narumi H, Suzuki T, Kainoh M, Taniguchi T, Chayama K.
Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e00183-17. doi: 10.1128/AAC.00183-17. Print 2017 Jun
https://www.ncbi.nlm.nih.gov/pubmed/28373196

Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous silibinin monotherapy.
DebRoy S, Hiraga N, Imamura M, Hayes CN, Akamatsu S, Canini L, Perelson AS, Pohl RT, Persiani S, Uprichard SL, Tateno C, Dahari H, Chayama K.
J Viral Hepat. 2016 Sep;23(9):708-17.
https://www.ncbi.nlm.nih.gov/pubmed/27272497

Interleukin-22-Induced Antimicrobial Phospholipase PLA2G2A Mediates Protective Innate Immunity of Non-hematopoietic cells against Listeria monocytogenes.
Okita Y, Shiono T, Yahagi A, Hamada S, Umemura M, Matsuzaki G.
Infect Immun. 2015 Dec 7;84(2):573-9.
http://www.ncbi.nlm.nih.gov/pubmed/26644377

Circulating microRNA Profiles in Patients with Type-1 Autoimmune Hepatitis.
Migita K, Komori A, Kozuru H, Jiuchi Y, Nakamura M, Yasunami M, Furukawa H, Abiru S, Yamasaki K, Nagaoka S, Hashimoto S, Bekki S, Kamitsukasa H, Nakamura Y, Ohta H, Shimada M, Takahashi H, Mita E, Hijioka T, Yamashita H, Kouno H, Nakamuta M, Ario K, Muro T, Sakai H, Sugi K, Nishimura H, Yoshizawa K, Sato T, Naganuma A, Komatsu T, Oohara Y, Makita F, Tomizawa M, Yatsuhashi H.
PLoS One. 2015 Nov 17;10(11):e0136908.
https://www.ncbi.nlm.nih.gov/pubmed/26575387

Differences in serum microRNA profiles in hepatitis B and C virus infection.
Akamatsu S, Hayes CN, Tsuge M, Miki D, Akiyama R, Abe H, Ochi H, Hiraga N, Imamura M, Takahashi S, Aikata H, Kawaoka T, Kawakami Y, Ohishi W, Chayama K.
J Infect. 2015 Mar;70(3):273-87.
http://www.ncbi.nlm.nih.gov/pubmed/25452043

Decreased miR-26a Expression Correlates with the Progression of Podocyte Injury in Autoimmune Glomerulonephritis.
Ichii O, Otsuka-Kanazawa S, Horino T, Kimura J, Nakamura T, Matsumoto M, Toi M, Kon Y.
PLoS One. 2014 Oct 17;9(10):e110383.
http://www.ncbi.nlm.nih.gov/pubmed/25329154

Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining.
Stanlie A, Yousif AS, Akiyama H, Honjo T, Begum NA.
Mol Cell. 2014 Jul 3;55(1):97-110.
https://www.ncbi.nlm.nih.gov/pubmed/24690901

Apoptotic response through a high mobility box 1 protein-dependent mechanism in LPS/GalN-induced mouse liver failure and glycyrrhizin-mediated inhibition.
Kuroda N, Inoue K, Ikeda T, Hara Y, Wake K, Sato T.
PLoS One. 2014 Apr 1;9(4):e92884.
http://www.ncbi.nlm.nih.gov/pubmed/24954901

Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA.
Kohno T, Tsuge M, Murakami E, Hiraga N, Abe H, Miki D, Imamura M, Ochi H, Hayes CN, Chayama K.
J Viral Hepat. 2014;21(9):e89-97.
http://www.ncbi.nlm.nih.gov/pubmed/24835118

Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.
Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley DM, Ishii KJ, Kiyono H, Akira S, Uematsu S.
Nat Commun. 2014 Mar 18;5:3492.
http://www.ncbi.nlm.nih.gov/pubmed/24637670

Circulating microRNAs in autoimmune thyroid diseases.
Yamada H, Itoh M, Hiratsuka I, Hashimoto S.
Clin Endocrinol (Oxf). 2014 Feb 17.
http://www.ncbi.nlm.nih.gov/pubmed/24533739

Downregulation of miR-15a due to LMP1 promotes cell proliferation and predicts poor prognosis in nasal NK/T-cell lymphoma.
Komabayashi Y, Kishibe K, Nagato T, Ueda S, Takahara M, Harabuchi Y.
Am J Hematol. 2014 Jan;89(1):25-33.
http://www.ncbi.nlm.nih.gov/pubmed/23963825

B-cell malignancies in microRNA Eμ-miR-17~92 transgenic mice.
Sandhu SK, Fassan M, Volinia S, Lovat F, Balatti V, Pekarsky Y, Croce CM.
Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18208-13.
http://www.ncbi.nlm.nih.gov/pubmed/24145403

The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice.
Ohno M, Shibata C, Kishikawa T, Yoshikawa T, Takata A, Kojima K, Akanuma M, Kang YJ, Yoshida H, Otsuka M, Koike K.
Sci Rep. 2013 Aug 30;3:2553.
http://www.ncbi.nlm.nih.gov/pubmed/23989853

Hepatitis B virus-specific miRNAs and Argonaute2 play a role in the viral life cycle.
Hayes CN, Akamatsu S, Tsuge M, Miki D, Akiyama R, Abe H, Ochi H, Hiraga N, Imamura M, Takahashi S, Aikata H, Kawaoka T, Kawakami Y, Ohishi W, Chayama K.
PLoS One. 2012;7(10):e47490.
http://www.ncbi.nlm.nih.gov/pubmed/23091627

The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through h2K4me3 regulation.
Begum NA, Stanlie A, Nakata M, Akiyama H, Honjo T.
J Biol Chem. 2012 Sep 21;287(39):32415-29.
http://www.ncbi.nlm.nih.gov/pubmed/22843687

The DSIF subunits Spt4 and Spt5 have distinct roles at various phases of immunoglobulin class switch recombination.
Stanlie A, Begum NA, Akiyama H, Honjo T.
PLoS Genet. 2012;8(4):e1002675.
http://www.ncbi.nlm.nih.gov/pubmed/22570620

Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene.
Nakajima A, Nishimura K, Nakaima Y, Oh T, Noguchi S, Taniguchi T, Tamura T.
Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12448-52.
http://www.ncbi.nlm.nih.gov/pubmed/19617565

PD-1+ memory phenotype CD4+ T cells expressing C/EBPalpha underlie T cell immunodepression in senescence and leukemia.
Shimatani K, Nakashima Y, Hattori M, Hamazaki Y, Minato N.
Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15807-12.
http://www.ncbi.nlm.nih.gov/pubmed/19805226

3D cultured immortalized human hepatocytes useful to develop drugs for blood-borne HCV.
Aly HH, Shimotohno K, Hijikata M.
Biochem Biophys Res Commun. 2009 Feb 6;379(2):330-4.
http://www.ncbi.nlm.nih.gov/pubmed/19103167