(1) analysis of miRNA in plasma or serum

Distinctive Tissue and Serum MicroRNA Profile of IgG4-Related Ophthalmic Disease and MALT Lymphoma.
Nezu N, Usui Y, Asakage M, Shimizu H, Tsubota K, Narimatsu A, Umazume K, Yamakawa N, Ohno SI, Takanashi M, Kuroda M, Goto H
J Clin Med. 2020 Aug 5;9(8):2530.
https://pubmed.ncbi.nlm.nih.gov/32764512/

Dementia subtype prediction models constructed by penalized regression methods for multiclass classification using serum microRNA expression data
Yuya Asanomi, Daichi Shigemizu, Shintaro Akiyama, Takashi Sakurai, Kouichi Ozaki,
Takahiro Ochiya, Shumpei Niida
Scientific Reports volume 11, Article number: 20947 (2021)
https://pubmed.ncbi.nlm.nih.gov/34686734/

miRNA-1246 in extracellular vesicles secreted from metastatic tumor induces drug resistance in tumor endothelial cells
Chisaho Torii, Nako Maishi, Taisuke Kawamoto, Masahiro Morimoto, Kosuke Akiyama , Yusuke Yoshioka, Takashi Minami, Takuya Tsumita, Mohammad Towfik Alam, Takahiro Ochiya, Yasuhiro Hida, Kyoko Hida
Sci Rep.2021 Jul 5;11(1):13502.
https://pubmed.ncbi.nlm.nih.gov/34226586/

Co-continuous structural effect of size-controlled macro-porous glass membrane on extracellular vesicle collection for the analysis of miRNA
Hiroshi Yukawa, Shuji Yamazaki, Keita Aoki, Kengo Muto, Naoto Kihara, Kazuhide Sato, Daisuke Onoshima, Takahiro Ochiya, Yasuhito Tanaka, Yoshinobu Baba
Sci Rep.2021 Apr 21;11(1):8672.
https://pubmed.ncbi.nlm.nih.gov/33883603/

Extracellular vesicles containing miR-146a-5p secreted by bone marrow mesenchymal cells activate hepatocytic progenitors in regenerating rat livers
Norihisa Ichinohe, Masayuki Ishii, Naoki Tanimizu, Toru Mizuguchi, Yusuke Yoshioka, Takahiro Ochiya, Hiromu Suzuki, Toshihiro Mitaka
Stem Cell Research & Therapy (2021) 12:312.
https://pubmed.ncbi.nlm.nih.gov/34051870/

MiR-199-3p enhances muscle regeneration and ameliorates aged muscle and muscular dystrophy
Masashi Fukuoka, Hiromi Fujita, Kosumo Numao, Yasuko Nakamura, Hideo Shimizu, Masayuki Sekiguchi & Hirohiko Hohjoh
Communications Biology volume 4, Article number: 427 (2021)
https://pubmed.ncbi.nlm.nih.gov/33782502/

Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss
Yuki Nakao, Takao Fukuda, Qunzhou Zhang, Terukazu Sanui, Takanori Shinjo, Xiaoxing Kou, Chider Chen, Dawei Liu, Yukari Watanabe, Chikako Hayashi, Hiroaki Yamato, Karen Yotsumoto, Urara Tanaka, Takaharu Taketomi, Takeshi Uchiumi, Anh D Le, Songtao Shi, Fusanori Nishimura
Acta Biomater.2020 Dec 24;S1742-7061(20)30769-8.doi: 10.1016/j.actbio.2020.12.046.
https://pubmed.ncbi.nlm.nih.gov/33359765/

Changes in circulating microRNA after recumbent isometric yoga practice by patients with myalgic encephalomyelitis/chronic fatigue syndrome: an explorative pilot study
Shu Takakura, Takakazu Oka, Nobuyuki Sudo
Biopsychosoc Med. 2019 Dec 2;13:29.
https://pubmed.ncbi.nlm.nih.gov/31827600

Blood levels of microRNAs associated with ischemic heart disease differ between Austrians and Japanese: a pilot study
Ichiro Wakabayashi, Ryoji Eguchi, Yoko Sotoda, Dirk von Lewinski, Harald Sourij, Takashi Daimon, Klaus Groschner, Peter P Rainer
Sci Rep. 2020 Aug 12;10(1):13628. doi: 10.1038/s41598-020-69332-0.
https://pubmed.ncbi.nlm.nih.gov/32788621

High-Throughput MicroRNA Profiling of Vitreoretinal Lymphoma: Vitreous and Serum MicroRNA Profiles Distinct From Uveitis
Teruumi Minezaki , Yoshihiko Usui, Masaki Asakage, Masakatsu Takanashi, Hiroyuki Shimizu, Naoya Nezu, Akitomo Narimatsu, Kinya Tsubota, Kazuhiko Umazume, Naoyuki Yamakawa, Masahiko Kuroda, Hiroshi Goto
J Clin Med. 2020 Jun 12;9(6):E1844. doi: 10.3390/jcm9061844
https://pubmed.ncbi.nlm.nih.gov/32545709

MicroRNA Expression Profiles of Neuron-Derived Extracellular Vesicles in Plasma From Patients With Amyotrophic Lateral Sclerosis
Masataka Katsu, Yuka Hama, Jun Utsumi, Ken Takashina, Hiroshi Yasumatsu, Fumiaki Mori, Koichi Wakabayashi, Mikio Shoji, Hidenao Sasaki
Neurosci Lett.2019 Aug 24;708:134176. doi: 10.1016/j.neulet.2019.03.048. Epub 2019 Jun 4.
https://pubmed.ncbi.nlm.nih.gov/31173847

Relationships among erythrocyte-derived microRNAs in serum of healthy donors.
Wakabayashi I, Sotoda Y, Eguchi R.
Clin Chim Acta. 2020 Mar 30. pii: S0009-8981(20)30136-4. doi: 10.1016/j.cca.2020.03.034.
https://www.ncbi.nlm.nih.gov/pubmed/32240657

Exploration of Exosomal Micro RNA Biomarkers Related to Epithelial-to-Mesenchymal Transition in Pancreatic Cancer
Sonohara F, Yamada S, Takeda S, Hayashi M, Suenaga M, Sunagawa Y, Tashiro M, Takami H, Kanda M, Tanaka C, Kobayashi D, Nakayama G, Koike M, Fujiwara M, Kodera Y.
Anticancer Res. 2020 Apr;40(4):1843-1853. doi: 10.21873/anticanres.14138
https://www.ncbi.nlm.nih.gov/pubmed/32234872

Highly Sensitive Circulating MicroRNA Panel for Accurate Detection of Hepatocellular Carcinoma in Patients With Liver Disease.
Yamamoto Y, Kondo S, Matsuzaki J, Esaki M, Okusaka T, Shimada K, Murakami Y, Enomoto M, Tamori A, Kato K, Aoki Y, Takizawa S, Sakamoto H, Niida S, Takeshita F, Ochiya T
Hepatol Commun. 2019 Dec 19;4(2):284-297. doi: 10.1002/hep4.1451. eCollection 2020 Feb.
https://www.ncbi.nlm.nih.gov/pubmed/32025611

Peripheral neuropathy from paclitaxel: risk prediction by serum microRNAs.
Noda-Narita S, Shimomura A, Tanabe Y, Kawauchi J, Matsuzaki J, Takizawa S, Aoki Y, Shimizu C, Tamura K, Ochiya T
BMJ Support Palliat Care. 2020 Jan 14. pii: bmjspcare-2019-001900. doi: 10.1136/bmjspcare-2019-001900.
https://www.ncbi.nlm.nih.gov/pubmed/31937590

Brain metastasis-related microRNAs in patients with advanced breast cancer.
Sato J, Shimomura A, Kawauchi J, Matsuzaki J, Yamamoto Y, Takizawa S, Sakamoto H, Ohno M, Narita Y, Ochiya T, Tamura K.
PLoS One. 2019 Oct 11;14(10):e0221538. doi: 10.1371/journal.pone.0221538. eCollection 2019
https://www.ncbi.nlm.nih.gov/pubmed/31603918

Serum microRNA profile enables preoperative diagnosis of uterine leiomyosarcoma.
Yokoi A, Matsuzaki J, Yamamoto Y, Tate K, Yoneoka Y, Shimizu H, Uehara T, Ishikawa M, Takizawa S, Aoki Y, Kato K, Kato T, Ochiya T
Cancer Sci. 2019 Dec;110(12):3718-3726. doi: 10.1111/cas.14215. Epub 2019 Nov 16
https://www.ncbi.nlm.nih.gov/pubmed/31599471

Exosomal hsa-miR-933 in Gastric Juice as a Potential Biomarker for Functional Dyspepsia.
Tanaka F, Takashima S, Nadatani Y, Otani K, Hosomi S, Kamata N, Taira K, Nagami Y, Tanigawa T, Fukumoto S, Watanabe T, Murakami Y, Kawada N, Fujiwara Y.
Dig Dis Sci. 2020 Jan 23. doi: 10.1007/s10620-020-06096-7.
https://www.ncbi.nlm.nih.gov/pubmed/31974910

A miRNA-based diagnostic model predicts resectable lung cancer in humans with high accuracy.
Asakura K, Kadota T, Matsuzaki J, Yoshida Y, Yamamoto Y, Nakagawa K, Takizawa S, Aoki Y, Nakamura E, Miura J, Sakamoto H, Kato K, Watanabe S, Ochiya T
Commun Biol. 2020 Mar 19;3(1):134. doi: 10.1038/s42003-020-0863-y
https://www.ncbi.nlm.nih.gov/pubmed/32193503

Plasma microRNA profiles: identification of miR-1229-3p as a novel chemoresistant and prognostic biomarker in gastric cancer.
Nishibeppu K, Komatsu S, Imamura T, Kiuchi J, Kishimoto T, Arita T, Kosuga T, Konishi H, Kubota T, Shiozaki A, Fujiwara H, Okamoto K, Otsuji E
Sci Rep. 2020 Feb 21;10(1):3161. doi: 10.1038/s41598-020-59939-8
https://www.ncbi.nlm.nih.gov/pubmed/32081926

Extracellular vesicles microRNA analysis in type 1 autoimmune pancreatitis: Increased expression of microRNA-21.
Nakamaru K, Tomiyama T, Kobayashi S, Ikemune M, Tsukuda S, Ito T, Tanaka T, Yamaguchi T, Ando Y, Ikeura T, Fukui T, Nishio A, Takaoka M, Uchida K, Leung PSC, Gershwin ME, Okazaki K
Pancreatology. 2020 Feb 21. pii: S1424-3903(20)30048-X. doi: 10.1016/j.pan.2020.02.012. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/32147308

Assessment of the Diagnostic Utility of Serum MicroRNA Classification in Patients With Diffuse Glioma.
Ohno M, Matsuzaki J, Kawauchi J, Aoki Y, Miura J, Takizawa S, Kato K, Sakamoto H, Matsushita Y, Takahashi M, Miyakita Y, Ichimura K, Narita Y, Ochiya T.
JAMA Netw Open. 2019 Dec 2;2(12):e1916953. doi: 10.1001/jamanetworkopen.2019.16953
https://www.ncbi.nlm.nih.gov/pubmed/31808923

Identification of serum microRNAs predicting the response of esophageal squamous-cell carcinoma to nivolumab.
Sudo K, Kato K, Matsuzaki J, Takizawa S, Aoki Y, Shoji H, Iwasa S, Honma Y, Takashima A, Sakamoto H6, Naka T, Sekine S, Boku N, Ochiya T.
Jpn J Clin Oncol. 2019 Oct 15. pii: hyz146. doi: 10.1093/jjco/hyz146
https://www.ncbi.nlm.nih.gov/pubmed/31612917

Serum microRNA-based prediction of responsiveness to eribulin in metastatic breast cancer
Satomi-Tsushita N, Shimomura A, Matsuzaki J, Yamamoto Y, Kawauchi J, Takizawa S3, Aoki Y, Sakamoto H, Kato K, Shimizu C, Ochiya T, Tamura K.
PLoS One. 2019 Sep 4;14(9):e0222024. doi: 10.1371/journal.pone.0222024. eCollection 2019
https://www.ncbi.nlm.nih.gov/pubmed/31483849

Development and Validation of an Esophageal Squamous Cell Carcinoma Detection Model by Large-Scale MicroRNA Profiling
Sudo K, Kato K, Matsuzaki J, Boku N, Abe S, Saito Y, Daiko H, Takizawa S, Aoki Y, Sakamoto H, Niida S, Takeshita F, Fukuda T, Ochiya T
JAMA Netw Open. 2019 May 3;2(5):e194573. doi: 10.1001/jamanetworkopen.2019.4573
https://www.ncbi.nlm.nih.gov/pubmed/31125107

A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes.
Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, Nakayama R, Morioka H, Matsumoto M, Nakamura M, Kondo T, Kato K, Tsuchiya N, Kawai A, Ochiya T
Nat Commun. 2019 Mar 21;10(1):1299. doi: 10.1038/s41467-019-09143-8
https://www.ncbi.nlm.nih.gov/pubmed/?term=A+serum+microRNA+classifier+for+the+diagnosis+of

Serum microRNAs and chronic periodontitis: A case-control study.
Yoneda T, Tomofuji T, Ekuni D, Azuma T, Maruyama T, Fujimori K, Sugiura Y, Morita M.
Arch Oral Biol. 2019 Mar 13;101:57-63. doi: 10.1016/j.archoralbio.2019.03.009.
https://www.ncbi.nlm.nih.gov/pubmed/30889506

Characterization of a novel microRNA, miR-188, elevated in serum of muscular dystrophy dog model.
Shibasaki H, Imamura M, Arima S, Tanihata J, Kuraoka M, Matsuzaka Y, Uchiumi F, Tanuma S, Takeda S.
PLoS One. 2019 Jan 30;14(1):e0211597. doi: 10.1371/journal.pone.0211597. eCollection 2019.
https://www.ncbi.nlm.nih.gov/pubmed/30699200

Risk prediction models for dementia constructed by supervised principal
component analysis using miRNA expression data.
Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S.
Commun Biol. 2019 Feb 25;2:77. doi: 10.1038/s42003-019-0324-7. eCollection 2019.
https://www.ncbi.nlm.nih.gov/pubmed/30820472

Large-scale circulating microRNA profiling for the liquid biopsy of prostate cancer.
Urabe F, Matsuzaki J, Yamamoto Y Kimura T, Hara T, Ichikawa M, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Egawa S, Fujimoto H, Ochiya T.
Clin Cancer Res. 2019 Feb 26. pii: clincanres.2849.2018. doi: 10.1158/1078-0432.CCR-18-2849.
https://www.ncbi.nlm.nih.gov/pubmed/30808771

Integrated extracellular microRNA profiling for ovarian cancer screening.
Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y, Takahashi K, Shimizu H, Uehara T, Ishikawa M, Ikeda S, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato K, Kato T, Ochiya T.
Nat Commun. 2018 Oct 17;9(1):4319. doi: 10.1038/s41467-018-06434-4.
https://www.ncbi.nlm.nih.gov/pubmed/30333487

Circulating microRNAs as potential biomarkers to detect transformation of Barrett's oesophagus to oesophageal adenocarcinoma.
Matsuzaki J1, Suzuki H.
BMJ Open Gastroenterol. 2017 Sep 8;4(1):e000160.
https://www.ncbi.nlm.nih.gov/pubmed/29177063

Depleted tumor suppressor miR-107 in plasma relates to tumor progression and is a novel therapeutic target in pancreatic cancer.
Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Konishi H, Shiozaki A, Morimura R, Ikoma H, Ochiai T, Okamoto K, Taniguchi H, Otsuji E.
Sci Rep. 2017 Jul 18;7(1):5708
https://www.ncbi.nlm.nih.gov/pubmed/28720759

MicroRNA Profiles Qualify Phenotypic Features of Cultured Human Corneal Endothelial Cells.
Ueno M, Asada K, Toda M, Hiraga A, Montoya M, Sotozono C, Kinoshita S, Hamuro J.
Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5509-5517.
https://www.ncbi.nlm.nih.gov/pubmed/27768788

Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target.
Tachibana H, Sho R, Takeda Y, Zhang X, Yoshida Y, Narimatsu H, Otani K, Ishikawa S, Fukao A, Asao H, Iino M.
PLoS One. 2016 Jul 21;11(7):e0159693.
https://www.ncbi.nlm.nih.gov/pubmed/27441818

Extracellular vesicle miR-7977 is involved in hematopoietic dysfunction of mesenchymal stromal cells via poly(rC) binding protein 1 reduction in myeloid neoplasms.
Horiguchi H, Kobune M, Kikuchi S, Yoshida M, Murata M, Murase K, Iyama S, Takada K, Sato T, Ono K, Hashimoto A, Tatekoshi A, Kamihara Y, Kawano Y, Miyanishi K, Sawada N, Kato J.
Haematologica. 2016 Apr;101(4):437-47
http://www.ncbi.nlm.nih.gov/pubmed/26802051

Novel combination of serum microRNA for detecting breast cancer in the early stage.
Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T.
Cancer Sci. 2016 Mar;107(3):326-34.
http://www.ncbi.nlm.nih.gov/pubmed/26749252

Microarray Technology and Its Applications for Detecting Plasma microRNA Biomarkers in Digestive Tract Cancers.
Konishi H, Ichikawa D, Arita T, Otsuji E.
Methods Mol Biol. 2016;1368:99-109.
http://www.ncbi.nlm.nih.gov/pubmed/26614071

Circulating microRNA Profiles in Patients with Type-1 Autoimmune Hepatitis.
Migita K, Komori A, Kozuru H, Jiuchi Y, Nakamura M, Yasunami M, Furukawa H, Abiru S, Yamasaki K, Nagaoka S, Hashimoto S, Bekki S, Kamitsukasa H, Nakamura Y, Ohta H, Shimada M, Takahashi H, Mita E, Hijioka T, Yamashita H, Kouno H, Nakamuta M, Ario K, Muro T, Sakai H, Sugi K, Nishimura H, Yoshizawa K, Sato T, Naganuma A, Komatsu T, Oohara Y, Makita F, Tomizawa M, Yatsuhashi H.
PLoS One. 2015 Nov 17;10(11):e0136908.
https://www.ncbi.nlm.nih.gov/pubmed/26575387

Plasma microRNA profiles: identification of miR-744 as a novel diagnostic and prognostic biomarker in pancreatic cancer.
Miyamae M, Komatsu S, Ichikawa D, Kawaguchi T, Hirajima S, Okajima W, Ohashi T, Imamura T, Konishi H, Shiozaki A, Morimura R, Ikoma H, Ochiai T, Okamoto K, Taniguchi H, Otsuji E.
Br J Cancer. 2015 Nov 17;113(10):1467-76.
http://www.ncbi.nlm.nih.gov/pubmed/26505678

Differences in serum microRNA profiles in hepatitis B and C virus infection.
Akamatsu S, Hayes CN, Tsuge M, Miki D, Akiyama R, Abe H, Ochi H, Hiraga N, Imamura M, Takahashi S, Aikata H, Kawaoka T, Kawakami Y, Ohishi W, Chayama K.
J Infect. 2015 Mar;70(3):273-87.
http://www.ncbi.nlm.nih.gov/pubmed/25452043

MicroRNA markers for the diagnosis of pancreatic and biliary-tract cancers.
Kojima M, Sudo H, Kawauchi J, Takizawa S, Kondou S, Nobumasa H, Ochiai A.
PLoS One. 2015 Feb 23;10(2):e0118220.
http://www.ncbi.nlm.nih.gov/pubmed/25706130

Plasma microRNA profiles: identification of miR-25 as a novel diagnostic and monitoring biomarker in oesophageal squamous cell carcinoma.
Komatsu S, Ichikawa D, Hirajima S, Kawaguchi T, Miyamae M, Okajima W, Ohashi T, Arita T, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Yagi N, Otsuji E.
Br J Cancer. 2014 Oct 14;111(8):1614-24.
http://www.ncbi.nlm.nih.gov/pubmed/25117812

Profiles of Extracellular miRNAs in the Aqueous Humor of Glaucoma Patients Assessed with a Microarray System.
Tanaka Y, Tsuda S, Kunikata H, Sato J, Kokubun T, Yasuda M, Nishiguchi KM, Inada T, Nakazawa T.
Sci Rep. 2014 May 28;4:5089.
http://www.ncbi.nlm.nih.gov/pubmed/24867291

Circulating microRNAs in autoimmune thyroid diseases.
Yamada H, Itoh M, Hiratsuka I, Hashimoto S.
Clin Endocrinol (Oxf). 2014 Feb 17.
http://www.ncbi.nlm.nih.gov/pubmed/24533739

Hepatitis B virus-specific miRNAs and Argonaute2 play a role in the viral life cycle.
Hayes CN, Akamatsu S, Tsuge M, Miki D, Akiyama R, Abe H, Ochi H, Hiraga N, Imamura M, Takahashi S, Aikata H, Kawaoka T, Kawakami Y, Ohishi W, Chayama K.
PLoS One. 2012;7(10):e47490.
http://www.ncbi.nlm.nih.gov/pubmed/23091627

Circulating microRNAs involved in multiple sclerosis.
Siegel SR, Mackenzie J, Chaplin G, Jablonski NG, Griffiths L.
Mol Biol Rep. 2012 May;39(5):6219-25. 
http://www.ncbi.nlm.nih.gov/pubmed/22231906

Detection of gastric cancer-associated microRNAs on microRNA microarray comparing pre- and post-operative plasma.
Konishi H, Ichikawa D, Komatsu S, Shiozaki A, Tsujiura M, Takeshita H, Morimura R, Nagata H, Arita T, Kawaguchi T, Hirashima S, Fujiwara H, Okamoto K, Otsuji E.
Br J Cancer. 2012 Feb 14;106(4):740-7. 
http://www.ncbi.nlm.nih.gov/pubmed/22262318