論文

(9)毒性(Toxicity)

Clioquinol induces DNA double-strand breaks, activation of ATM, and subsequent activation of p53 signaling.
Katsuyama M, Iwata K, Ibi M, Matsuno K, Matsumoto M, Yabe-Nishimura C.
Toxicology. 2012 Sep 4;299(1):55-9. 
http://www.ncbi.nlm.nih.gov/pubmed/22627294

Toxicological effect of emodin in mouse testicular gene expression profile.
Oshida K, Hirakata M, Maeda A, Miyoshi T, Miyamoto Y.
J Appl Toxicol. 2011 Nov;31(8):790-800. 
http://www.ncbi.nlm.nih.gov/pubmed/21319176

A possible mechanism for hepatotoxicity induced by BIRB-796, an orally active p38 mitogen-activated protein kinase inhibitor.
Iwano S, Asaoka Y, Akiyama H, Takizawa S, Nobumasa H, Hashimoto H, Miyamoto Y.
J Appl Toxicol. 2011 Oct;31(7):671-7
http://www.ncbi.nlm.nih.gov/pubmed/21328587

Novel gene markers of immunosuppressive chemicals in mouse lymph node assay.
Oshida K, Maeda A, Kitsukawa M, Suga S, Iwano S, Miyoshi T, Miyamoto Y.
Toxicol Lett. 2011 Aug 10;205(1):79-85. 
http://www.ncbi.nlm.nih.gov/pubmed/21621594

A newly developed DNA microarray is useful to assess induction of cytochromes p450 in the cynomolgus monkey.
Ise R, Uehara S, Akiyama H, Kondo S, Iwasaki K, Nagata R, Nobumasa H, Yamazaki H, Uno Y.
Drug Metab Pharmacokinet. 2011 Jun;26(3):228-35. 
http://www.ncbi.nlm.nih.gov/pubmed/21273731

Identification of AhR-regulated genes involved in PAH-induced immunotoxicity using a highly-sensitive DNA chip, 3D-Gene Human Immunity and Metabolic Syndrome 9k.
Iwano S, Ichikawa M, Takizawa S, Hashimoto H, Miyamoto Y.
Toxicol In Vitro. 2010 Feb;24(1):85-91. 
http://www.ncbi.nlm.nih.gov/pubmed/19737606