論文

(8) シグナル伝達・代謝関連 (signaling・metabolism)

Role of S1P/S1PR3 axis in release of CCL20 from human bronchial epithelial cells.
Kawa Y, Nagano T, Yoshizaki A, Dokuni R, Katsurada M, Terashita T, Yasuda Y, Umezawa K, Yamamoto M, Kamiryo H, Kobayashi K, Nishimura Y.
PLoS One. 2018 Sep 7;13(9):e0203211
https://www.ncbi.nlm.nih.gov/pubmed/30192865

ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells.
Yamagami M, Otsuka M, Kishikawa T, Sekiba K, Seimiya T, Tanaka E, Suzuki T, Ishibashi R, Ohno M, Koike K.
NPJ Aging Mech Dis. 2018 Nov 15;4:11
https://www.ncbi.nlm.nih.gov/pubmed/30455980

Dectin-2 Deficiency Modulates Th1 Differentiation and Improves Wound Healing After Myocardial Infarction. Yan X, Zhang H, Fan Q, Hu J, Tao R, Chen Q, Iwakura Y, Shen W, Lu L, Zhang Q, Zhang R. Circ Res. 2017 Mar 31;120(7):1116-1129.
https://www.ncbi.nlm.nih.gov/pubmed/28193608

The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure.
Ono T, Kamimura N, Matsuhashi T, Nagai T, Nishiyama T, Endo J, Hishiki T, Nakanishi T, Shimizu N, Tanaka H, Ohta S, Suematsu M, Ieda M, Sano M, Fukuda K, Kaneda R.
Sci Rep. 2017 Jan 4;7:39752.
https://www.ncbi.nlm.nih.gov/pubmed/28051130

Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-κB Signaling Pathway.
Ohtsu N, Nakatani Y, Yamashita D, Ohue S, Ohnishi T, Kondo T.
Cancer Res. 2016 Jan 1;76(1):171-81.
https://www.ncbi.nlm.nih.gov/pubmed/26677976

ΔNp63α induces quiescence and downregulates the BRCA1 pathway in estrogen receptor-positive luminal breast cancer cell line MCF7 but not in other breast cancer cell lines.
Amin R, Morita-Fujimura Y, Tawarayama H, Semba K, Chiba N, Fukumoto M, Ikawa S.
Mol Oncol. 2015 Nov 24. pii: S1574-7891(15)00208-2.
http://www.ncbi.nlm.nih.gov/pubmed/26704768

Interferon-β Mediates Signaling Pathways Uniquely Regulated in Hepatic Stellate Cells and Attenuates the Progression of Hepatic Fibrosis in a Dietary Mouse Model.
Shimozono R, Nishimura K, Akiyama H, Funamoto S, Izawa A, Sai T, Kunita K, Kainoh M, Suzuki T, Kawada N.
J Interferon Cytokine Res. 2015 Jun;35(6):464-73.
http://www.ncbi.nlm.nih.gov/pubmed/25715168

Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart.
Matsuhashi T, Hishiki T, Zhou H, Ono T, Kaneda R, Iso T, Yamaguchi A, Endo J, Katsumata Y, Atsushi A, Yamamoto T, Shirakawa K, Yan X, Shinmura K, Suematsu M, Fukuda K, Sano M.
J Mol Cell Cardiol. 2015 May;82:116-24.
http://www.ncbi.nlm.nih.gov/pubmed/25744081

MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis.
Katsura A, Morishita A, Iwama H, Tani J, Sakamoto T, Tatsuta M, Toyota Y, Fujita K, Kato K, Maeda E, Nomura T, Miyoshi H, Yoneyama H, Himoto T, Fujiwara S, Kobara H, Mori H, Niki T, Ono M, Hirashima M, Masaki T.
Int J Mol Med. 2015 Apr;35(4):877-84.
http://www.ncbi.nlm.nih.gov/pubmed/25672270

Transcriptional program of Kpna2/Importin-α2 regulates cellular differentiation-coupled circadian clock development in mammalian cells.
Umemura Y, Koike N, Matsumoto T, Yoo SH, Chen Z, Yasuhara N, Takahashi JS, Yagita K.
Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):E5039-48.
http://www.ncbi.nlm.nih.gov/pubmed/25389311

microRNA regulation of endothelin-1 mRNA in renal collecting duct cells.
Jacobs ME, Jeffers LA, Welch AK, Wingo CS, Cain BD.
Life Sci. 2014 Nov 24;118(2):195-9.
http://www.ncbi.nlm.nih.gov/pubmed/24632479

Distinct microRNA expression profiles in mouse renal cortical tissue after 177Lu-octreotate administration.
Schuler E, Parris TZ, Helou K, Forssell-Aronsson E.
PLoS One. 2014 Nov 11;9(11):e112645.
http://www.ncbi.nlm.nih.gov/pubmed/25386939

Crosstalk between the Rb Pathway and AKT Signaling Forms a Quiescence-Senescence Switch.
Imai Y, Takahashi A, Hanyu A, Hori S, Sato S, Naka K, Hirao A, Ohtani N, Hara E.
Cell Rep. 2014 Apr 10;7(1):194-207.
http://www.ncbi.nlm.nih.gov/pubmed/24703840

miR-192 Induces G2/M Growth Arrest in Aristolochic Acid Nephropathy.
Jenkins RH, Davies LC, Taylor PR, Akiyama H, Cumbes B, Beltrami C, Carrington CP, Phillips AO, Bowen T, Fraser DJ.
Am J Pathol. 2014 Apr;184(4):996-1009.
http://www.ncbi.nlm.nih.gov/pubmed/24508230

Apoptotic response through a high mobility box 1 protein-dependent mechanism in LPS/GalN-induced mouse liver failure and glycyrrhizin-mediated inhibition.
Kuroda N, Inoue K, Ikeda T, Hara Y, Wake K, Sato T.
PLoS One. 2014 Apr 1;9(4):e92884.
https://www.ncbi.nlm.nih.gov/pubmed/24690901

Myostatin signaling regulates Akt activity via the regulation of miR-486 expression.
Hitachi K, Nakatani M, Tsuchida K.
Int J Biochem Cell Biol. 2014 Feb;47:93-103.
http://www.ncbi.nlm.nih.gov/pubmed/24342526

Deficiency of NOX1/nicotinamide adenine dinucleotide phosphate, reduced form oxidase leads to pulmonary vascular remodeling.
Iwata K, Ikami K, Matsuno K, Yamashita T, Shiba D, Ibi M, Matsumoto M, Katsuyama M, Cui W, Zhang J, Zhu K, Takei N, Kokai Y, Ohneda O, Yokoyama T, Yabe-Nishimura C.
Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):110-9.
http://www.ncbi.nlm.nih.gov/pubmed/24233492

Expression profiling of ETO2-regulated miRNAs in erythroid cells: Possible influence on miRNA abundance. Fujiwara T, Okitsu Y, Katsuoka Y, Fukuhara N, Onishi Y, Ishizawa K, Harigae H. FEBS Open Bio. 2013 Oct 11;3:428-32.
http://www.ncbi.nlm.nih.gov/pubmed/24251106

Knockdown of human TCF4 affects multiple signaling pathways involved in cell survival, epithelial to mesenchymal transition and neuronal differentiation.
Forrest MP, Waite AJ, Martin-Rendon E, Blake DJ.
PLoS One. 2013 Aug 23;8(8):e73169.
http://www.ncbi.nlm.nih.gov/pubmed/24058414

MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis.
Ogawa T, Enomoto M, Fujii H, Sekiya Y, Yoshizato K, Ikeda K, Kawada N.
Gut. 2012 Nov;61(11):1600-9.
http://www.ncbi.nlm.nih.gov/pubmed/22267590

Gene expression analysis using a high-resolution DNA microarray of peripheral whole blood immediately before and after leukocytapheresis for rheumatoid arthritis.
Kusaoi M, Yamaji K, Murayama G, Yasui M, Yamada R, Hishinuma R, Nemoto T, Hohtatsu K, Kageyama M, Kawamoto T, Sugimoto K, Sekiya F, Kon T, Ogasawara M, Kempe K, Tsuda H, Takasaki Y.
Ther Apher Dial. 2012 Oct;16(5):456-66.
http://www.ncbi.nlm.nih.gov/pubmed/23046371

Synthesis and biological properties of highly sequence-specific-alkylating N-methylpyrrole-N-methylimidazole polyamide conjugates.
Kashiwazaki G, Bando T, Yoshidome T, Masui S, Takagaki T, Hashiya K, Pandian GN, Yasuoka J, Akiyoshi K, Sugiyama H.
J Med Chem. 2012 Mar 8;55(5):2057-66.
http://www.ncbi.nlm.nih.gov/pubmed/2309169

Different responses to oxidized low-density lipoproteins in human polarized macrophages.
Hirose K, Iwabuchi K, Shimada K, Kiyanagi T, Iwahara C, Nakayama H, Daida H.
Lipids Health Dis. 2011 Jan 4;10:1
http://www.ncbi.nlm.nih.gov/pubmed/21199582

OGFOD1, a member of the 2-oxoglutarate and iron dependent dioxygenase family, functions in ischemic signaling.
Saito K, Adachi N, Koyama H, Matsushita M.
FEBS Lett. 2010 Aug 4;584(15):3340-7.
http://www.ncbi.nlm.nih.gov/pubmed/20579638

The microRNA miR-696 regulates PGC-1{alpha} in mouse skeletal muscle in response to physical activity.
Aoi W, Naito Y, Mizushima K, Takanami Y, Kawai Y, Ichikawa H, Yoshikawa T.
Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E799-806
http://www.ncbi.nlm.nih.gov/pubmed/20086200

Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart.
Endo J, Sano M, Katayama T, Hishiki T, Shinmura K, Morizane S, Matsuhashi T, Katsumata Y, Zhang Y, Ito H, Nagahata Y, Marchitti S, Nishimaki K, Wolf AM, Nakanishi H, Hattori F, Vasiliou V, Adachi T, Ohsawa I, Taguchi R, Hirabayashi Y, Ohta S, Suematsu M, Ogawa S, Fukuda K.
Circ Res. 2009 Nov 20;105(11):1118-27.
http://www.ncbi.nlm.nih.gov/pubmed/19815821